KNK437

Catalog No.: A14389
pan-HSP inhibitor
KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
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Product Name Price Stock Qty
KNK437 10mg
$60.00
In stock
KNK437 50mg
$250.00
In stock
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Biological Activity
Discription KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells.
Targets
Target Value
Product Information
Catalog Num A14389
Formula C13H11NO4
Molecular Weight 245.23
CAS Number 218924-25-5
SMILES O=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O
Synonyms KNK-437, KNK 437
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO Warmed: 14 mg/mL (57.08 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+corn oil 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 40.78 mL 203.89 mL 407.78 mL
0.5 mM 8.16 mL 40.78 mL 81.56 mL
1 mM 4.08 mL 20.39 mL 40.78 mL
5 mM 0.82 mL 4.08 mL 8.16 mL
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