LEE011 (Ribociclib)

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CDK4/6 inhibitor

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Catalog No. A13549

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LEE011 10mg A13549-10

Regular Price: $80.00

Special Price: $68.00

LEE011 25mg A13549-25

Regular Price: $120.00

Special Price: $102.00

LEE011 50mg A13549-50

Regular Price: $150.00

Special Price: $127.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

LEE011 (Ribociclib)

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Chemical Information

Catalog Num A13549
Actions Inhibitor
M. Wt 434.54
Formula C23H30N8O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1211441-98-3
Synonyms LEE-011, LEE 011
SMILES code CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
Chemical Name 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Biological Activity

Description
LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
Targets
CDK4 (Cell-free assay) CDK6 (Cell-free assay)

Solubility

Solubility (25°C)* In vitro DMSO 7 mg/mL (16.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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