Lipase



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Catalog No. Product Name Application Product Information
A13814

Atglistatin

ATGL inhibitor
Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM.
A15944

Cetilistat (ATL-962)

lipase inhibitor
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine.
A10229

Clofibrate

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Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL.
A14704

Dihydroberberine

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Dihydroberberine is an inhibitor of pancreatic lipase with IC50 value of 8 mg/ml.
A13774

JW-642

MAGL inhibitor
JW-642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
A12747

JZL184

MAGL Inhibitor
JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
A12390

JZL195

dual FAAH/MAGL inhibitor
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
A16081

MJN110

MAGL inhibitor
MJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA).
A10676 SALE

Orlistat

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Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.
A10890 SALE

Tanshinone IIA (Tanshinone B)

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Tanshinone IIA (TIIA) is one of the major extracts obtained from Salvia miltiorrhiza BUNGE, which has anti-inflammatory and anti-apoptotic effects on many diseases.
A16359

URB602

MGL inhibitor
URB602 is a selective inhibitor of monoglycerol lipase (MGL), exhibiting an IC50 of 28 uM for the rat brain enzyme.
A11095

URB754

Monoacylglycerol lipase inhibitor
URB754 was originally reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase.
A13150 SALE

XEN445

Endothelial lipase(EL) inhibitor
XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.

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