• Sign In
  • FAQ
  • Create an Account
Currency
USD currency flagUSD
Toggle Nav
My Cart
Menu
Account
Settings
Currency
USD currency flagUSD

MAPK

Items 1-50 of 815

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Citations
  1. A24447
    DB0614

    Kinases PROTAC/Nek9 Inhibitor

    DB0614 is a PROTAC molecule utilizing a cereblon ligand, designed as a selective and potent degrader of NEK9 and other kinases. It induces the degradation of multiple kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1–3, MAP4K5, MAPK14, MAPK7–9, MAPKAPK2/3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1/3, SIK2/3, STK35, TNK2, and ULK1. DB0614 is suitable for research involving diseases or disorders driven by aberrant kinase activity.
    Quick View
  2. A24154
    Keracyanin chloride

    NF-κB/FAK/MAPK inhibitor

    Keracyanin chloride is an orally active anthocyanin compound with potent antioxidant, anti-inflammatory, and hypoglycemic properties. It exerts its biological effects by inhibiting the NF-κB/FAK/MAPK signaling pathways, which are central to inflammation, cell adhesion, and metabolic regulation.
    Quick View
  3. A24134
    MAPK-IN-1

    MAPK inhibitor

    MAPK-IN-1 (Compound 2) is an inhibitor of the MAPK signaling pathway with demonstrated neuroprotective and anti-neuroinflammatory properties. It also exhibits acetylcholinesterase (AChE) inhibitory activity, with an IC₅₀ of 23.84 μM, contributing to enhanced cholinergic signaling. These combined actions make MAPK-IN-1 a promising candidate for research in Alzheimer's disease and other neurodegenerative disorders, where modulation of MAPK signaling and cholinergic function are of therapeutic interest.
    Quick View
  4. A10001
    Sorafenib Tosylate (Nexavar)

    Raf inhibitor

    Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
    Quick View
  5. A10002
    PLX-4720

    Raf inhibitor

    PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf.
    Quick View
  6. A10089
    AS703026 (Pimasertib)

    MEK1/2 inhibitor

    AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
    Quick View
  7. A10092
    Asiatic acid

    Anti-inflammatory agent

    Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

    Quick View
  8. A10115
    AZD8330

    MEK Inhibitor

    AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
    Quick View
  9. A10148
    Doramapimod (BIRB-796)

    p38 MAPK inhibitor

    Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
    Quick View
  10. A10150
    BIX02188

    MEK5 inhibitor

    BIX02188 is a potent and selective inhibitor of MEK5.
    Quick View
  11. A10151
    (E/Z)-BIX 02189

    MEK inhibitor

    BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
    Quick View
  12. A10212
    PD184352 (CI-1040)

    MEK1/2 inhibitor

    PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
    Quick View
  13. A10250
    Regorafenib (BAY 73-4506)

    VEGFR inhibitor

    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.
    Quick View
  14. A10256
    Mirdametinib (PD0325901)

    MEK inhibitor

    PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
    Quick View
  15. A10257
    AZD6244 (Selumetinib)

    MEK inhibitor

    AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
    Quick View
  16. A10420
    GDC-0879

    B-Raf inhibitor

    GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM).
    Quick View
  17. A10453
    Honokiol

    Antiangiogenic and Antitumor Agent

    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
    Quick View
  18. A10545
    LY2228820 dimesylate (Ralimetinib dimesylate)

    p38 MAPK inhibitor

    LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
    Quick View
  19. A10661
    NVP-BHG712

    EphB4 inhibitor

    NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
    Quick View
  20. A10704
    PD318088

    MEK Inhibitor

    PD318088 is an inhibitor of MEK1 AND MEK2.
    Quick View
  21. A10705
    PD98059

    MEK Inhibitor

    PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
    Quick View
  22. A10739
    PLX4032 (Vemurafenib)

    Raf inhibitor

    PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
    Quick View
  23. A10773
    RAF265 (CHIR-265)

    RAF/VEGFR Inhibitor

    RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.
    Quick View
  24. A10774
    Raf265 derivative

    RAF/VEGFR Inhibitor

    Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM.
    Quick View
  25. A10823
    SB 202190

    p38 MAPK Inhibitor

    SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.
    Quick View
  26. A10824
    Adezmapimod (SB-203580)

    p38 MAPK inhibitor

    SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
    Quick View
  27. A10829
    SB590885

    B-Raf Inhibitor

    SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.
    Quick View
  28. A10860
    SP600125

    JNK inhibitor

    SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.
    Quick View
  29. A10895
    Pexmetinib (ARRY-614)

    p38 MAPK inhibitor

    Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
    Quick View
  30. A10957
    U0126-EtOH

    MEK inhibitor

    U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
    Quick View
  31. A10970
    AMG 548

    p38 MAPK inhibitor

    AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
    Quick View
  32. A10982
    VX-702

    p38 MAPK inhibitor

    VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).
    Quick View
  33. A10983
    Neflamapimod (VX-745)

    p38 MAPK inhibitor

    VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
    Quick View
  34. A11029
    Trametinib (GSK1120212, JTP-74057)

    MEK Inhibitor

    Trametinib (GSK1120212, JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.

    Quick View
  35. A11040
    TAK-733

    MEK Inhibitor

    TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
    Quick View
  36. A11063
    AZ628

    Raf inhibitor

    AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
    Quick View
  37. A11077
    ZM 336372

    C-Raf inhibitor

    ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells.
    Quick View
  38. A11078
    PH-797804

    p38 MAPK inhibitor

    PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
    Quick View
  39. A11101
    SKF 86002 Dihydrochloride

    p38 MAPK inhibitor

    SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM).
    Quick View
  40. A11211
    ML 786 dihydrochloride

    Raf inhibitor

    ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively).
    Quick View
  41. A11221
    PD 169316

    p38 MAPK inhibitor

    PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM.
    Quick View
  42. A11225
    Pluripotin (SC-1)

    ERK1/RasGAP Inhibitor

    The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.
    Quick View
  43. A11240
    MLN2480 (BIIB-024)

    pan-Raf inhibitor

    MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials.
    Quick View
  44. A11247
    RO4927350

    MEK1/2 inhibitor

    RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
    Quick View
  45. A11264
    Refametinib

    MEK inhibitor

    Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
    Quick View
  46. A11271
    Anisomycin

    SAPKs/JNKs activator

    Anisomycin is a pyrrolidine antibiotic, acts as an anti-fungal antibiotic which inhibits Protein Synthesis, also is a potent activator of SAPKs/JNKs.
    Quick View
  47. A11281
    AEG 3482

    JNK inhibitor

    AEG 3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis.
    Quick View
  48. A11282
    PF-3644022

    MK2 Inhibitor

    PF-3644022 is a potent and selective mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) inhibitor (Ki =3 nM).
    Quick View
  49. A11296
    AS 602801 (Bentamapimod)

    JNK inhibitor

    AS 602801 is a novel, orally active, Jun Kinase Inhibitor.
    Quick View
  50. A11321
    Skepinone-L

    p38 MAPK inhibitor

    Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
    Quick View

Items 1-50 of 815

Page
per page
Set Descending Direction
Shop By
Shopping Options
Category
Actions
  1. Inhibitor 218items
  2. Agonist 1item
  3. Activator 4items
  4. Inducer 1item
Target
  1. PARP1 1item
  2. ERK1 30items
  3. ERK2 43items
  4. ERK5 16items
  5. ERK8 2items