HDAC

Inhibitory Selectivity
Catalog No.Inhibitor Name HDAC HDAC1 HDAC2 HDAC3 HDAC4HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2
A10979Vorinostat
****
A10611Entinostat
**
*
A10518Panobinostat
****
A10947Trichostatin A
****
A10586Mocetinostat
**
**
*
*
A10122Belinostat
***
A11920Romidepsin
***
***
A10560MC1568
*
A11042Tubastatin A HCl
*
***
A10488Givinostat
****
****
A10516Dacinostat
***
A10246CUDC-101
****
****
***
****
***
***
****
**
**
**
***
A10830Pracinostat
***
**
***
***
***
*
**
**
**
***
**
A11152PCI-34051
*
*
****
*
A10337Droxinostat
*
*
*
A10700Abexinostat
****
***
****
***
**
***
A13218RGFP966
**
A11037AR-42
***
A11940Ricolinostat
**
***
***
*
*
****
*
**
A11964Tacedinaline
*
*
*
**
A11153CUDC-907
****
****
****
**
*
***
**
**
****
****
A11355M344
**
A10954Tubacin
****
A13139RG2833
***
****
A12556Resminostat
***
***
**
A15489BRD73954
*
***
**
A11361BG45
*
*
**
A143544SC-202
*
*
*
A16431CAY10603
**
****
A14341LMK-235
***
****
A14032Nexturastat A
****
A14128TMP269
**
**
***
***
A14197HPOB
*
*
*
***
*
*
A12722Scriptaid
A12616Tasquinimod
A11042Tubastatin A
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A14354 SALE

4SC-202

HDAC inhibitor
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.
A11940 SALE

ACY-1215 (Rocilinostat)

HDAC6 inhibitor
ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
A12758 SALE

ACY-241

HDAC6 inhibitor
ACY-241 is a new, selective and orally available inhibitor of HDAC6.
A15934 SALE

ACY-738

HDAC6 inhibitor
ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.
A12745

Apicidin

HDAC inhibitor
Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity.
A11037

AR-42 (HDAC-42)

HDAC inhibitor
AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
A10122 SALE

Belinostat (PXD101)

HDAC inhibitor
Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM.
A11361

BG45

HDAC inhibitor
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 ??M, respectively).
A15935 SALE

BML-210

HDAC inhibitor‎
BML-210 is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.
A15489 SALE

BRD73954

HDAC inhibitor
BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).
A12911

BRD9757

HDAC6 inhibitor
BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6.
A10179 SALE

Carbamazepine

-
Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia.
A16431

CAY10603

HDAC6 inhibitor
CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.
A11964 SALE

CI994 (Tacedinaline)

HDAC Inhibitor
CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells.
A10246 SALE

CUDC-101

HDAC inhibitor
CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.
A11153 SALE

CUDC-907

HDAC inhibitor
CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
A10337 SALE

Droxinostat

HDAC inhibitor
Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.
A14197 SALE

HPOB

HDAC6 inhibitor
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).
A10488

ITF2357 (Givinostat)

HDAC inhibitor
ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
A16127

ITSA-1

HDAC inhibitor
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors.
A10492 SALE

JNJ-26481585

HDAC inhibitor
JNJ-26481585 is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L).
A15354

KD 5170

HDAC inhibitor
KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
A10516 SALE

LAQ824 (NVP-LAQ824)

HDAC Inhibitor
LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
A10518 SALE

LBH589 (Panobinostat)

HDAC Inhibitor?
LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
A14341 SALE

LMK-235

HDAC4/5 inhibitor
LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor.

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