Orexin Receptors

Actions
  1. Antagonist (4)


4 Item(s)

per page

Set Descending Direction
Catalog No. Product Name Application Product Information
A11500

MK-4305 (Suvorexant)

OX receptor antagonist
Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.
A12786

SB 334867

OX1 receptor antagonist
SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.
A12651

SB-649868

Orexin Antagonist
SB-649868 is an orexin receptor antagonist in development by GlaxoSmithKline.
A13439

TCS 1102

Dual orexin receptor antagonist
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).

4 Item(s)

per page

Set Descending Direction