Others

AL082D06 is a nonsteroidal glucocorticoid receptor antagonist.

PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.

L-Threonine derivative-1 is a acetylsalicylic-L-threonine ester extracted from patent US 20060287244 A1.

Butylphthalide is an antioxidant and one of the chemical constituents in celery oil, along with sedanolide, which is primarily responsible for the aroma and taste of celery.

N-563 is an analogue of deoxyspergualin with an immunostimulating activity,it promotes resistance to Candida albicans infection in mice.

W-2429 is a non-narcotic analgesic agent.

M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC).

Dimethyl 4-hydroxyisophthalate is a methyl salicylate analogue.

TAK-778 is a derivative of ipriflavone and has been shown to induce bone growth in in vitro and in vivo models.

CP 375 is a Fe3+ chelating agent, with a log K1 value of 14.50.

TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator.

3-arylisoquinolinamine derivative is a 3-arylisoquinolinamine derivative with antitumor activity.

CI-943 is a potential antipsychotic agent.

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

RP 54275 (2-Octadecyl-1H-indole-5-carboxylic acid) is a novel hypocholesterolaemic drug.

Ipenoxazone is a potent and centrally acting muscle relaxant.

Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity.

Emixustat, a novel visual cycle modulator, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro.

nipradilol is an alpha(1),beta-blocker with a nitric oxide donative action

Pristinamycin is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections.

Nalbuphine is a semi-synthetic opioid agonist-antagonist analgesic of the phenanthrene series

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM.

Stiripentol is an epilepsy drug. It has been used as co-therapy for treatment of epilepsy

ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

WF-11899A is a novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899

N/A

Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities.

N/A

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

RGH-5526 (GYKI-11679) is a new antihypertensive agent.

UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.

Mepixanox (Pimexone) is an analeptic drug used in respiratory and cardiorespiratory insufficiency.

20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE).

IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2.

Pirazolac is a non-steroidal anti-inflammatory drug.

Prifuroline is an antiarrhythmic agent.

Pirozadil is a hypolipidemic agent.

(±)-WS75624B is an endothelin converting enzyme (ECE) inhibitor with an IC50 of 0.03 μg/mL.

Clozic is a potential anti-arthritic agent.

Tepilamide fumarate (XP-23829) is an oral fumaric acid ester, acts as a prodrug of monomethyl fumarate, and is used in the research of moderate to severe chronic plaque psoriasis.

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.

Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.

BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme

Substituted piperidines-1 is a compound that can promote the release of growth hormone in humans and animals.

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors.

CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

(E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker.