Catalog No.
Product Name
Application
Product Information
Product Citation
- Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities.
- Teglarinad chloride, also known as GMX1777, is a water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond.
- Pyronaridine Tetraphosphate is a common antimalarial agent that has been found to enhance the antitumor activity of doxorubicin against multidrug-resistant cancers K562/A02 and MCF-7/ADR.
- Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria
- Viktoria Lazar, .et al. , Nature, 2022, 610: 540-546 PMID: 36198788
- Zewen Wen, .et al. , J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Telavancin is a semi-synthetic vancomycin analogue prepared by the addition of a decylaminoethyl moiety to the free amino group of the disaccharide.
- Adam J Plaunt, .et al. , Antimicrob Agents Chemother, 2021, May 3;AAC.00316-21 PMID: 33941518
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squalene epoxidase inhibitor
FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. -
synthesized plant gowth regulator
Prohydrojasmon racemate is a synthesized plant gowth regulator. - RC-3095 is a bombesin/gastrin-releasing peptide (BN/GRP) antagonist with potential anticancer activity.
- Paula J.S. Pereira, .et al. , J Neurosci, 2015, Dec 9; 35(49): 16272-16281 PMID: 26658875
- Tirapazamine is a bioreductive, anti-neoplastic, anti-cancer agent that is selectively toxic to cells under hypoxic conditions.
- Zhu R, .et al. , Biomacromolecules, 2019, May 24 PMID: 31125209
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Neutrophil elastase inhibitor
Freselestat is a potent neutrophil elastase inhibitor. Freselestat reduces inflammatory mediators during simulated extracorporeal circulation. ONO-6818 significantly reduced interleukin 8 and C5b-9 production. ONO-6818 did not modulate changes of CD11b and L-selectin during recirculation. - Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue.
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Histone-H2A peptide
Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. - Prochloraz manganese is a sterol C-14 demethylation inhibitor which impairs biosynthesis of ergosterol, an essential compound for the stability and functioning of lipoprotein membranes
- Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity.
- Sally L George, .et al. , EBioMedicine, 2020, Aug 23;59:102971 PMID: 32846370
- Ibutamoren, also known as MK-677 (L-163,191), is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin.
- Cardiolipin is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition.
- Ceftobiprole medocaril is a fifth-generation[2] cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and enterococci.
- Cangrelor is a potent intravenous adenosine diphosphate-receptor antagonist
- Satoru Koyanagi, .et al. , Nat Commun, 2016, 7: 13102 PMID: 27739425
- D2PM (hydrochloride) is a psychoactive designer drug that has recently been demonstrated to have toxic effects in humans.
- Lomifylline is a methylxanthine analogue which induces Ca2+-release from intracellular stores via the ryanodine receptor.
- Tafenoquine is an 8-aminoquinoline drug manufactured by GlaxoSmithKline that is being investigated as a potential treatment for malaria, as well as for malaria prevention.
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MC4 antagonist
SNT207858 is a 22 nM MC4 antagonist with a 170-fold selectivity vs. MC3 and a 40-fold selectivity versus MC5. - 4-Epi Minocycline is an impurity of Minocyclin, a second generation tetracycline antibiotic.
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O-GlcNAcase inhibitor
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal-hexosaminidase.- Kefan Wu, .et al. , Biomedicines, 2023, Apr 24;11(5):1259 PMID: 37238930
- Wei Zhong Zhu, .et al. , PLoS One, 2022, Oct 26;17(10):e0276285 PMID: 36288343
- Zhu WZ, .et al. , J Am Heart Assoc, 2019, Jun 4;8(11):e011260 PMID: 31131693
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SCD1 inhibitor
stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice. - Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of ??-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.
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cytoplasmic dynein antagonist
Ciliobrevin D is the first specific small molecule antagonist of cytoplasmic dynein -
glycolate oxidase inhibitor
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV. -
AKR1C3 inhibitor
AKR1C3-IN-1 is a potent, highly selective inhibitor of AKR1C3, with an IC50 of 13 nM. - GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4?CNKX2-5 transcriptional synergy with an IC50 of 3 μM.
- Benzophenonetetracarboxylic acid (3,3',4,4'-Benzophenonetetracarboxylic acid) is particularly useful in the preparation of high performance polyimides and also useful as curing agents for epoxy resins.
