P-gp

Inhibitory Selectivity
Catalog No.Inhibitor Name P-gpOther
A10549Zosuquidar 3HCl
**
A11584Tariquidar
***
A12324Elacridar (GF120918)
BCRP

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



15 Item(s)

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Catalog No. Product Name Application Product Information
A15289

Zosuquidar

P-gp inhibitor
Zosuquidar is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
A15077 SALE

Elacridar hydrochloride

P-gp inhibitor
Elacridar hydrochloride is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
A10549 SALE

LY335979 (Zosuquidar 3HCl)

P-gp modulator
LY335979 (Zosuquidar trihydrochloride) is a potent highly selective P-gp inhibitor.
A16080

MC 70 HCl

P-gp inhibitor
MC-70 is a potent P-gp inhibitor (EC50 = 0.69 uM).
A13533

Biricodar (VX-710)

P-gp modulator
Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.
A13532

Laniquidar

P-gp inhibitor
Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters.
A13531

ONT-093

P-gp inhibitor
ONT-093 is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy.
A13660 SALE

SC-144

gp130 inhibitor
SC-144 is an orally active small-molecule gp130 inhibitor.
A13961

XR9576

P-glycoprotein inhibitor
XR9576 is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer
A12004 SALE

Cynarin

-
Cynarin is a phenolic compound found in artichoke. It has antioxidant and choleretic properties. It is a potential immunosuppressive agent.
A12363

Selamectin

-
N/A
A11584 SALE

Tariquidar (XR9576)

P-gp inhibitor
Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.
A12324 SALE

Elacridar (GF120918)

P-gp & BCRP inhibitor
Elacridaris a prototypical BCRP inhibitor which inhibits the Bcrp1-mediated transport.
A11080

PSC-833 (Valspodar)

MDR1/P-gp Inhibitor
PSC-833 is a kind of P-glycoprotein (P-gp) modulator that inhibits P-gp-mediated multidrug-resistance (MDR).
A16195

KS-176

BCRP inhibitor
KS-176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 uM in Pheo A and Hoechst 33342 assays respectively).

15 Item(s)

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