PERK

Inhibitory Selectivity
Catalog No.Inhibitor Name PERKOther
A12792GSK2606414
****
EIF2AK1 (HRI),EIF2AK2 (PKR)
A13577GSK2656157
***
A13816ISRIB (trans-isomer)
**
A12676Salubrinal

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A12792 SALE

GSK2606414

PERK inhibitor
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
A13577

GSK2656157

PERK Inhibitor II
GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
A14302

ISRIB

PERK inhibitor
ISRIB, the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM.
A13816 SALE

ISRIB (trans-isomer)

PERK inhibitor
ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation.
A12676 SALE

Salubrinal

-
Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

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