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Items 51 to 100 of 1755 total

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Catalog No. Product Name Application Product Information Sale Price
A10770

R406 (Tamatinib) SALE

Syk Inhibitor
R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling.

Special Price Starting at: $104.00

A10134

BI 2536 SALE

PLK inhibitor
BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.

Special Price Starting at: $56.00

A10743

Pomalidomide (CC-4047) SALE

TNF-alpha inhibitor
Pomalidomide is a derivative of thalidomide and acts as an immunomodulator.

Special Price Starting at: $32.00

A10947

Trichostatin-A (TSA) SALE

HDAC Inhibitor
Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.

Special Price Starting at: $144.00

A10906

Temsirolimus (Torisel) SALE

mTOR inhibitor
Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells.

Special Price Starting at: $48.00

A10095

AT9283 SALE

Aurora/JAK inhibitor
AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.

Special Price Starting at: $64.00

A10122

Belinostat (PXD101) SALE

HDAC inhibitor
Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM.

Special Price Starting at: $48.00

A10082

Apixaban (BMS-562247-01) SALE

Factor Xa inhibitor
Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.

Special Price Starting at: $40.00

A10868

Streptozotocin (Zanosar) SALE

O-GlcNAcase inhibitor
Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro.

Special Price Starting at: $48.00

A11411

Dovitinib (TKI-258) SALE

RTK inhibitor
Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.

Special Price Starting at: $32.00

A10985

VX-770 (Ivacaftor) SALE

CFTR activator
VX-770 (Ivacaftor) is known as a CFTR potentiator.

Special Price Starting at: $56.00

A10998

Foretinib (GSK1363089, XL880) SALE

c-MET inhibitor
Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.

Special Price Starting at: $32.00

A11017

LY2157299 SALE

TGF-βR Inhibitor
LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor.

Special Price Starting at: $72.00

A10141

BIBW2992 (Afatinib) SALE

EGFR inhibitor
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.

Special Price Starting at: $32.00

A10116

AZD8931 (Sapitinib) SALE

pan-EGFR/pan-erbB inhibitor
AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.

Special Price Starting at: $72.00

A10782

Rapamycin (Sirolimus) SALE

mTOR Inhibitors
Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2).

Special Price Starting at: $32.00

A11020

PCI-32765 (Ibrutinib) SALE

Bruton tyrosine kinase inhibitor
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.

Special Price Starting at: $40.00

A10212

PD184352 (CI-1040) SALE

MEK1/2 inhibitor
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Special Price Starting at: $32.00

A10160

Bortezomib (Velcade) SALE

Proteasome inhibitor
Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome

Special Price Starting at: $24.00

A11021

NVP-AEW541 SALE

IGF-1R inhibitor
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

Special Price Starting at: $64.00

A10935

Tipifarnib (Zarnestra) SALE

FTase inhibitor
Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.

Special Price Starting at: $120.00

A10080

AP24534 (Ponatinib) SALE

BCR-ABL inhibitor
AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.

Special Price Starting at: $32.00

A10607

Mosapride citrate SALE

5-HT4-receptor agonist
Mosapride citrate acts as 5-HT4 receptor agonist and 5-HT3 receptor antagonist.

Special Price Starting at: $32.00

A10928

Thiazovivin SALE

ROCK inhibitor
Thiazovivin is a selective inhibitor of Rho-associated kinase (ROCK).

Special Price Starting at: $60.00

A10957

U0126-EtOH SALE

MEK inhibitor
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

Special Price Starting at: $40.00

A10010

17-AAG (KOS953) SALE

HSP90 inhibitor
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.

Special Price Starting at: $32.00

A10659

AUY922 (Luminespib, NVP-AUY922) SALE

HSP90 Inhibitor
AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.

Special Price Starting at: $32.00

A10143

BIIB021 SALE

HSP90 inhibitor
BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.

Special Price Starting at: $44.00

A10159

BMS-790052 (Daclatasvir) SALE

HCV NS5A inhibitor
BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.

Special Price Starting at: $48.00

A10185

Cediranib (AZD2171) SALE

VEGFR inhibitor
Cediranib (AZD2171) s a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.

Special Price Starting at: $32.00

A10111

Olaparib (AZD2281) SALE

PARP inhibitor
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.

Special Price Starting at: $32.00

A10773

RAF265 (CHIR-265) SALE

RAF/VEGFR Inhibitor
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.

Special Price Starting at: $96.00

A10986

VX-809 (Lumacaftor) SALE

CFTR modulator
VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).

Special Price Starting at: $80.00

A11001

Y-27632 2HCl SALE

ROCK Inhibitor
Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).

Special Price Starting at: $48.00

A11014

ZSTK474 SALE

PI3K inhibitor
ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms.

Special Price Starting at: $40.00

A10518

LBH589 (Panobinostat) SALE

HDAC Inhibitor
LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.

Special Price Starting at: $40.00

A10463

IC-87114 SALE

PI3K Inhibitor
IC-87114 was the first isoform-selective PI3K inhibitor :p110M-NM-4(IC50 = 0.13 M-BM-5M) vs. p110M-NM-1(IC50 = 200 M-BM-5M), p110M-NM-2(IC50 = 16 M-BM-5M) and p110M-NM-3(IC50 = 61 M-BM-5M).

Special Price Starting at: $40.00

A10109

AZD1152-HQPA (Barasertib) SALE

Aurora Kinase B inhibitor
AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases.

Special Price Starting at: $64.00

A10113

AZD7762 SALE

Chk1 & Chk2 inhibitor
AZD7762 is a potent ATP-competitive checkpoint kinase inhibitor that drives checkpoint abrogation and potentiates DNA-targeted therapies.

Special Price Starting at: $32.00

A10726

PI-103 SALE

PI3K Inhibitor
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.

Special Price Starting at: $40.00

A10995

XL147 analogue SALE

PI3K Inhibitor
XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity.

Special Price Starting at: $80.00

A10172

CAL-101 (GS-1101, Idelalisib) SALE

PI3K inhibitor
CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.

Special Price Starting at: $32.00

A10438

GSK1059615 SALE

mTOR/PI3K Inhibitor
GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM).

Special Price Starting at: $56.00

A10922

TG100-115 SALE

PI3K Inhibitor
TG100-115 inhibits PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively).

Special Price Starting at: $48.00

A10422

Gefitinib (Iressa) SALE

EGFR Inhibitor
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.

Special Price Starting at: $32.00

A10362

Erlotinib HCl SALE

EGFR inhibitor
Erlotinib hydrochloride is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).

Special Price Starting at: $32.00

A10514

Lapatinib Ditosylate SALE

HER2 inhibitor
Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.

Special Price Starting at: $32.00

A11022

AG-1478 (Tyrphostin AG-1478) SALE

EGFR Inhibitor
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.

Special Price Starting at: $32.00

A10374

Everolimus (RAD001) SALE

mTOR inhibitor
Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

Special Price Starting at: $48.00

A10101

Tivozanib (AV-951) SALE

VEGFR Inhibitor
Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.

Special Price Starting at: $32.00

Items 51 to 100 of 1755 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction