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Items 101 to 150 of 1755 total

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Catalog No. Product Name Application Product Information Sale Price
A10381

Fasudil HCl (HA-1077) SALE

ROCK inhibitor
Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).

Special Price Starting at: $40.00

A10505

KU-0063794 SALE

mTOR Inhibitor
KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively).

Special Price Starting at: $40.00

A11023

GDC-0980 (Apitolisib, RG7422) SALE

mTOR/PI3K Inhibitor
GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.

Special Price Starting at: $48.00

A10652

Norfloxacin (Norxacin) SALE

Topoisomerase inhibitor
Norfloxacin(Norxacin) is a broad-spectrum antibiotic.

Special Price Starting at: $36.00

A11024

PF-04691502 SALE

PI3K/mTOR Inhibitor
PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway.

Special Price Starting at: $56.00

A10981

VX-680 (MK-0457, Tozasertib) SALE

Aurora Kinase inhibitor
VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

Special Price Starting at: $32.00

A10170

Butylscopolamine BR (Scopolamine butylbromide) SALE

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Butylscopolamine BR is an orally available bromide salt form of butylscopolamine which is a peripherally acting antimuscarinic, anticholinergic agent.

Special Price Starting at: $40.00

A10560

MC1568 SALE

HDAC Inhibitor
MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis.

Special Price Starting at: $40.00

A10715

Danusertib (PHA-739358) SALE

Aurora inhibitor
Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2

Special Price Starting at: $80.00

A10420

GDC-0879 SALE

B-Raf inhibitor
GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM).

Special Price Starting at: $72.00

A10029

Acarbose SALE

Anti-Diabetic Agent
Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes.

Special Price Starting at: $48.00

A10089

AS703026 (Pimasertib) SALE

MEK1/2 inhibitor
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.

Special Price Starting at: $32.00

A10142

Bicalutamide (Casodex) SALE

Androgen Receptor antagonist
Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism.

Special Price Starting at: $32.00

A10471

Indirubin SALE

CDK & GSK-3β inhibitor
Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.

Special Price Starting at: $32.00

A11062

Onalespib (AT13387) SALE

HSP90 Inhibitor
AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.

Special Price Starting at: $72.00

A10678

OSI-420 SALE

EGFR Inhibitor
OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by inhibition of the intercellular domain .

Special Price Starting at: $88.00

A10246

CUDC-101 SALE

HDAC inhibitor
CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.

Special Price Starting at: $56.00

A10164

BSI-201 (Iniparib) SALE

PARP inhibitor
BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.

Special Price Starting at: $48.00

A10045

AG-014699 (Rucaparib) SALE

PARP inhibitor
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.

Special Price Starting at: $48.00

A10046

AG14361 SALE

PARP inhibitor
AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.

Special Price Starting at: $80.00

A10019

A-966492 SALE

PARP1 inhibitor
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.

Special Price Starting at: $72.00

A11026

MK-4827 (Niraparib) SALE

PARP inhibitor
MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

Special Price Starting at: $72.00

A10242

CP-724714 SALE

HER2/ErbB2 inhibitor
CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) .

Special Price Starting at: $48.00

A11209

BMS 599626 (AC480) SALE

EGFR Inhibitor
BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.

Special Price Starting at: $64.00

A10137

Bibf1120 (Vargatef) SALE

VEGFR inhibitor
BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR.

Special Price Starting at: $32.00

A11029

GSK1120212 (JTP-74057, Trametinib) SALE

MEK Inhibitor
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.

Special Price Starting at: $32.00

A10746

PP242 (Torkinib) SALE

mTOR Inhibitor
PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.

Special Price Starting at: $40.00

A11064

YM201636 SALE

PI3K Inhibitor
YM201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM).

Special Price Starting at: $72.00

A10047

AG-490 SALE

EGFR inhibitor
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

Special Price Starting at: $24.00

A10838

SGI-1776 (free base) SALE

PIM1 Inhibitor
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

Special Price Starting at: $68.00

A10043

AEE788 SALE

EGFR inhibitor
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.

Special Price Starting at: $72.00

A10693

Palomid 529 (P529) SALE

AKT Inhibitor
Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation.

Special Price Starting at: $80.00

A11030

GSK690693 SALE

AKT inhibitor
GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).

Special Price Starting at: $60.00

A11031

CCT128930 SALE

AKT Inhibitor
CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference.

Special Price Starting at: $82.40

A11032

PHT-427 SALE

AKT Inhibitor
PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

Special Price Starting at: $40.00

A11033

Triciribine phosphate (NSC-280594) SALE

AKT Inhibitor
Triciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation.

Special Price Starting at: $64.00

A11034

A-674563 SALE

Akt inhibitor
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

Special Price Starting at: $112.00

A10869

SU11274 SALE

c-Met inhibitor
SU11274 is a Met tyrosine kinase inhibitor.

Special Price Starting at: $48.00

A10713

PHA-665752 SALE

c-Met Inhibitor
PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.

Special Price Starting at: $40.00

A10839

SGX-523 SALE

c-Met Inhibitor
SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.

Special Price Starting at: $32.00

A10493

JNJ-38877605 SALE

c-Met inhibitor
c-Met inhibitor JNJ-38877605 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways.

Special Price Starting at: $48.00

A10153

BMS-777607 SALE

c-Met inhibitor
BMS-777607 is a MET tyrosine kinase inhibitor that binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.

Special Price Starting at: $56.00

A10711

PF-04217903 SALE

c-Met Inhibitor
PF-04217903 is a novel c-Met/hepatocyte growth factor receptor tyrosine kinase inhibitors.

Special Price Starting at: $40.00

A10806

Roscovitine (Seliciclib) SALE

CDK Inhibitor
Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.

Special Price Starting at: $64.00

A10469

Imiquimod (Aldara) SALE

TLR7 agonist
Imiquimod (Aldara) is a a heterocyclic imidazoquinoline amide that acts as an immune response modifier.

Special Price Starting at: $36.00

A10703

PD173074 SALE

FGFR1/VEGFR2 Inhibitor
PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.

Special Price Starting at: $24.00

A10506

KU-55933 SALE

ATM inhibitor
KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.

Special Price Starting at: $32.00

A10805

Rolipram SALE

PDE4 inhibitor
Rolipram is a PDE4-inhibitor with IC50 = 2.0 μM.

Special Price Starting at: $40.00

A10953

TSU-68 (Orantinib, SU6668) SALE

PDFGRβ inhibitor
Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.

Special Price Starting at: $40.00

A11035

GSK2126458 (Omipalisib) SALE

mTOR/PI3K Inhibitor,
GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models.

Special Price Starting at: $64.00

Items 101 to 150 of 1755 total

per page
Page:
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  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction