Proteases

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. Proteasome inhibitor

    ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies.
  2. Neutrophil elastase inhibitor

    Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).
  3. HIV-1 maturation inhibitor

  4. Hec1 Inhibitor

    INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
  5. angiotensin receptor-neprilysin inhibitor

    LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.
  6. Cysteine Protease inhibitor

    MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
  7. metalloendopeptidase inhibitor

    Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor.
  8. Calpain inhibitor

    PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 uM for μ-Calpain, about 20-fold selectivity over m-calpain.
  9. MMP-2/MMP-9 inhibitor

    SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9.
  10. HIV protease inhibitor

    Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.
  11. aspartic protease inhibitor

    Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.
  12. serine protease inhibitor

    Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion.
  13. serine protease inhibitor

    AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
  14. phosphatase inhibitor

    (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
  15. Irreversible Cysteine Protease inhibitor

    Z-FA-FMK is an irreversible cysteine protease inhibitor.
  16. CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.
  17. DPP-4 inhibitor

    Trelagliptin is a highly selective, long-acting DPP-4 inhibitor.
  18. eIF2α phosphatase inhibitor

    Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
  19. protein phosphatase inhibitor

    Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.
  20. Caspase-9 Inhibitor

    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
  21. DDP-4 inhibitor

    Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
  22. Glutaminase inhibitor

    CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. CB-839 (Telaglenastat) also inudces autophagy and has antitumor activity.

  23. osteoblast differentiation inducer

    Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP?\2/p38 and ERK1/2 pathway. Asperosaponin ?? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.
  24. 20S proteasome inhibitor

    Aclarubicin A, an anthracycline drug, specific inhibitor of the 20S proteasome chymotrypsin-like activity.
  25. Calpain Inhibitor

    Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain I, calpain II, cathepsin L and cathepsin B with Ki values of 120 nM, 230 nM, 0.6 nM and 100 nM, respectively.
  26. Elastase Inhibitor is a potent, irreversible inhibitor of human neutrophil elastase (HNE).
  27. HLE inhibitor

    Elastase Inhibitor, SPCK is a potent, irreversible inhibitor of human leukocyte elastase (HLE) (Ki = 10 uM).
  28. Caspase inhibitor

    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
  29. Caspase inhibitor

    Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.
  30. Caspase-3/7 Inhibitor

    Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
  31. 20S proteasome inhibitor

    AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.
  32. Proteasome inhibitor

    Dihydroeponemycin is an inhibitor of proteasome and antitumor reagent.
  33. BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM.
  34. Reversible thrombin inhibitor

    Bivalirudin is a synthetic 20 residue peptide which reversibly inhibits thrombin.
  35. HIV-1 attachment inhibitor

    BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
  36. HIV-1 attachment inhibitor

    BMS-663068 tris is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
  37. CPG2 inhibitor

    Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.
  38. direct thrombin inhibitor

    Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
  39. thrombin inhibitor

    Dabigatran ethyl ester, which is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity.
  40. HIV protease inhibitor

    Fosamprenavir Calcium Salt is a phosphate ester prodrug of the antiretroviral protease inhibitor amprenavir, with improved solubility over the parent molecule and a potential for reduced pill burden on current dosing regimens; GW433908G is the calcium salt of the prodrug.
  41. gamma-secretase modulator

    gamma-secretase modulator 3 is a gamma-secretase modulator.
  42. HCV Protease inhibitor

    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.
  43. HCV Protease inhibitor

    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.
  44. HCV Protease inhibitor

    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.
  45. HCV replication inhibitor

    RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM).
  46. DPP-4 inhibitor

    Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.
  47. HIV protease inhibitor

    Tipranavir, a nonpeptidic HIV protease inhibitor (NPPI), inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-PI-resistant HIV-1 isolates.
  48. Selective calpain inhibitor

    Acetyl-Calpastatin (184-210) (human), selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 uM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
  49. Fluorogenic caspase substrate

    Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
  50. MMP-2 inhibitor

    ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM.

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