Ras



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Catalog No. Product Name Application Product Information
A16097

6H05

K-Ras inhibitor
6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).
A14235

6H05 (trifluoroacetate salt)

K-Ras inhibitor
6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).
A16376

AMI5

protein methyltransferase inhibitor
AMI5 is a non-selective protein methyltransferase inhibitor.
A16175

APS-2-79 HCl

KSR/Ras inhibitor
APS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).
A13119

Balamapimod (MKI-833)

Ras/Raf/MEK inhibitor
Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor.
A14956

BQU57

GTPase Ral inhibitor
BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.
A14430

CCG-1423

Rho inhibitor
CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription.
A12740

EHop-016

Rac GTPase Inhibitor
EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration.
A13112

GGTI-2418

GGTase inhibitor
GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways.
A14227 SALE

K-Ras(G12C) inhibitor 12

K-Ras(G12C) inhibitor
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
A14103 SALE

K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor
K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP.
A14250

K-Ras(G12C) inhibitor 9

K-Ras(G12C) inhibitor
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
A13135 SALE

Kobe0065

-
Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells.
A12578

Kobe2602

Ras–Raf inhibitor
Kobe2602 is an analog of Kobe0065. Exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.
A15925

ML-098

Rab7 activator
ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM).
A12546 SALE

NSC 23766

Rac1 activation inhibitor
NSC 23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 ??M) without affecting Cdc42 or RhoA activation.
A11572

Salirasib

PPMTase inhibitor
Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki value of 2.6 uM.
A16049

XRP44X

Ras-Net inhibitor
XRP44X is a Ras-Net (Elk-3) pathway inhibitor (IC50 = 10-20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation.
A13403 SALE

ZCL-278

Cdc42 GTPase inhibitor
ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
A11010 SALE

Zoledronic Acid

osteoclastic bone resorption inhibitor
Zoledronic acid is a bisphosphonate which used to multiple myeloma and prostate cancer treament.

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