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Catalog No. Product Name Application Product Information
A12590

(+)-Bicuculline

GABAA antagonist
(+)-Bicuculline is a classical GABAA antagonist.
A10005 SALE

(-)-Epigallocatechin gallate

Antioxidant, antiangiogenic, antitumor agent
(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.
A11997 SALE

(S)-10-Hydroxycamptothecin

Topoisomerase
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis.
A10010 SALE

17-AAG (KOS953)

HSP90 inhibitor
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.
A10011 SALE

17-DMAG HCl (Alvespimycin)

Hsp90 inhibitor
17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.
A10012 SALE

2-Methoxyestradiol

Apoptotic, antiproliferative and antiangiogenic agent
2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
A10013

3-Indolebutyric acid

-
is a plant hormone in the auxin family and is an ingredient in many commercial horticultural plant rooting products.
A11151 SALE

3-Methyladenine

Autophagy/PI3K Inhibitor
3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase).
A10015 SALE

4-Methylumbelliferone (4-MU)

-
4-Methylumbelliferone is a selective inhibitor of Hyaluronan (HA) synthesis which is thought to function as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis.
A11166 SALE

5-hydroxymethyl tolterodine (PNU 200577)

muscarinic receptor antagonist

5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

A10017 SALE

5-hydroxytryptophan (5-HTP)

-
5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.
A11234 SALE

A 803467

Sodium channel Blocker
A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).
A11199

A 922500

DGAT-1 inhibitor

A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively).

A11034 SALE

A-674563

Akt inhibitor
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
A11071 SALE

A-769662

AMPK activator
A-769662 is a new activator of AMP-activated protein kinase (AMPK).
A10019 SALE

A-966492

PARP inhibitor
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
A11202

A66

PI3K inhibitor
The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA).
A10022 SALE

ABT-263 (Navitoclax)

Bcl-2 inhibitor
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .
A10255 SALE

ABT-737

Bcl-2 Inhibitor
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
A10024 SALE

ABT-751 (E-7010)

Microtubule Associated inhibitor
ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.
A10026

ABT-888 (Veliparib)

PARP inhibitor
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A10027 SALE

AC220 (Quizartinib)

FLT3 inhibitor
AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.
A10029 SALE

Acarbose

Anti-Diabetic Agent
Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes.
A10031 SALE

Acetanilide

Hydrogen peroxide inhibitor
Acetanilide is used as an inhibitor in hydrogen peroxide and is used to stabilize cellulose ester varnishes.
A10032 SALE

Acetylcysteine

-

Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Oral acetylcysteine is also used for the prevention of radiocontrast-induced nephropathy (a form of acute renal failure).

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