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Catalog No. Product Name Application Product Information
A10250 SALE

Regorafenib (BAY 73-4506)

VEGFR inhibitor
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.
A10251 SALE

Flupirtine maleate

NMDA antagonist
Non-opioid analgesic with muscle relaxant properties.
A10252

Dihydromyricetin (Ampeloptin)

Dihydropyrimidinase Inhibitor
Dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) is a natural antioxidant with good prospects.
A10255 SALE

ABT-737

Bcl-2 Inhibitor
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
A10256 SALE

PD0325901

MEK inhibitor
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
A10257

AZD6244 (Selumetinib)

MEK inhibitor
AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
A10258 SALE

GDC-0449 (Vismodegib)

Hedgehog antagonist
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
A10022 SALE

ABT-263 (Navitoclax)

Bcl-2 inhibitor
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .
A10562 SALE

MDV3100

Androgen receptor antagonist
MDV3100 is androgen-receptor inhibitor. Highly recommended inhibitor in AR research.
A10665 SALE

Obatoclax mesylate (GX15-070)

Bcl-2 Inhibitor
Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
A10802 SALE

RO4929097

Gamma-secretase inhibitor
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
A10611 SALE

MS-275 (Entinostat)

HDAC inhibitor
MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.
A10070

Ammonium Glycyrrhizinate (AMGZ)

Dehydrogenase inhibitor
Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste.
A10758 SALE

PTC124 (Ataluren)

CFTR inhibitor
PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
A11041

INCB018424 (Ruxolitinib)

JAK1/2 Inhibitor
INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;
A10001 SALE

Sorafenib (Nexavar)

Raf inhibitor
Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
A10002

PLX-4720

Raf inhibitor
PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.
A10003 SALE

MK-2206 2HCl

AKT Inhibitor
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
A10004 SALE

MLN8237 (Alisertib)

Aurora A Kinase inhibitor
MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3..
A10005 SALE

(-)-Epigallocatechin gallate

Antioxidant, antiangiogenic, antitumor agent
(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.
A10547 SALE

LY294002

PI3K Inhibitor
LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor.
A10027 SALE

AC220 (Quizartinib)

FLT3 inhibitor
AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.
A10705

PD98059

MEK Inhibitor
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
A10114 SALE

AZD8055

mTOR Inhibitor
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
A11002 SALE

YM155 (Sepantronium Bromide)

Survivin Inhibitor
YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
A10110 SALE

AZD1480

JAK Inhibitor
AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM.
A10461 SALE

Ibuprofen (Advil)

COX-1 inhibitor
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.
A10448 SALE

Hesperadin

Aurora B Kinase inhibitor
Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.
A10860 SALE

SP600125

JNK inhibitor
SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.
A10103 SALE

Axitinib

VEGFR inhibitor
Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
A10862 SALE

SRT1720 HCl

SIRT1 Activator
SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
A10706 SALE

Pelitinib (EKB-569)

EGFR inhibitor
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
A10408 SALE

FTY720 (Fingolimod)

S1P Receptor antagonist
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.
A10996 SALE

XL184 free base (Cabozantinib)

VEGFR inhibitor
XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2.
A10602 SALE

MLN9708

Proteasome Inhibitor
MLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome.
A10390 SALE

Flavopiridol (Alvocidib)

CDK inhibitor
Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.
A11016 SALE

BKM120 (NVP-BKM120, Buparlisib)

PI3K Inhibitor‎
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
A10026

ABT-888 (Veliparib)

PARP inhibitor
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A10739 SALE

PLX4032 (Vemurafenib)

Raf inhibitor
PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
A10421 SALE

GDC-0941 (Pictilisib)

PI3K inhibitor
GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively.
A10108 SALE

Saracatinib (AZD0530)

Src/Abl inhibitor
Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
A11018 SALE

TAK-875 (Fasiglifam)

GPR agonist
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.
A10112 SALE

AZD6482

PI3K inhibitor
AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy.
A10558 SALE

Masitinib ( AB1010)

c-Kit inhibitor
Masitinib (AB1010) is a protein tyrosine kinase inhibitor.
A10769 SALE

R406 besylate

Syk Inhibitor
R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
A10770 SALE

R406 (Tamatinib)

Syk Inhibitor
R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling.
A10134 SALE

BI 2536

PLK inhibitor
BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
A10743 SALE

Pomalidomide (CC-4047)

TNF-alpha inhibitor
Pomalidomide is a derivative of thalidomide and acts as an immunomodulator.
A10947 SALE

Trichostatin-A (TSA)

HDAC Inhibitor
Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.
A10906 SALE

Temsirolimus (Torisel)

mTOR inhibitor
Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells.

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