S1P Receptor



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Catalog No. Product Name Application Product Information
A16290

MP-A08

ATP competitive SK inhibitor
MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ±0.8 uM and 27 ± 3 uM, respectively.
A16289

K145 hydrochloride

SphK2 inhibitor
K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent.
A16288

K145

SphK2 inhibitor
K145 is a selective SphK2 inhibitor with an IC50 of 4.30± 0.06 μM , while no inhibition of SphK1 at concentrations up to 10 uM.
A15988

SKI-II

SphK Inhibitor
SKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 uM).
A13307

Ponesimod

S1P1 receptor modulator
Ponesimod is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.
A15833

NS13001

SK2 modulator
NS13001 is a selective SK2/3 modulator that acts as a potential therapeutic agent for treatment of SCA2 and possibly other cerebellar ataxias.
A15819

RPC1063 (Ozanimod)

S1PR1 modulators
RPC1063 is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-?associated diseases.
A15210

PF-543 Citrate

SphK1 Inhibitor
PF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
A13637

CYM 5442 HCl

EDG-1 (S1P1) agonist
CYM 5442 HCl is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM).
A12614 SALE

ABC294640

SphK2 inhibitor
ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity.
A13039 SALE

PF-543

SphK1 inhibitor
PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine.
A12906

BAF312 (Siponimod)

S1PR1/S1PR5 inhibitor
BAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 and S1P5.
A10408 SALE

FTY720 (Fingolimod)

S1P Receptor antagonist
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.

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