Serine Protease

Inhibitory Selectivity
Catalog No.Inhibitor Name Serine ProteaseOther
A14263Aprotinin
***
Thrombin,Trypsin,kallikrein
A12779Alvelestat (AZD9668)
****
A10617Nafamostat Mesylate
A11901PMSF
cysteine protease
A14145Leupeptin Hemisulfate
Cysteine protease
A14270AEBSF HCl

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10617 SALE

Nafamostat mesylate

serine protease inhibitor
Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
A11901

PMSF

Serine/cysteine protease inhibitor
PMSF is an irreversible serine/cysteine protease inhibitor.
A15315

SSR 69071

HLE inhibitor
SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM).
A13605

AAF-CMK

Serine protease inhibitor
AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI).
A14184

Sivelestat

Neutrophil elastase inhibitor
Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).
A14263 SALE

Aprotinin

serine protease inhibitor
Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion.
A14270 SALE

AEBSF HCl

serine protease inhibitor
AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
A14145

Leupeptin hemisulfate

Cysteine Protease inhibitor
Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain.
A12779 SALE

Alvelestat

neutrophil elastase inhibitor
Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).
A14073

Sivelestat sodium salt

Neutrophil elastase inhibitor
Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.
A11764

Camostat mesylate

-
Camostat mesylate is an orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin.
A11325

BCX 1470 methanesulfonate

Serine protease inhibitor
BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.
A11331

BCX 1470

Serine protease inhibitor
BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.
A16137

Sivelestat sodium hydrate (ONO-5046 sodium hydrate)

Neutrophil elastase inhibitor
Sivelestat sodium is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

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