All 'ATR' Products



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Catalog No. Product Name Application Product Information
A13205

AZ-20

ATR kinase inhibitor
AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM.
A15794

AZD6738

ATR inhibitor
AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
A13191

CGK 733

ATM/ATR inhibitor
CGK733 is a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells.
A13328

ETP-46464

ATR inhibitor
A11098

NU-7441 (KU-57788)

DNA-PK inhibitor
NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.
A14136

NU6027

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NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 ??M) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
A12752

NU7026

DNA-PK inhibitor
NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
A11991

Schisandrin B

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Schisandrin B is the most abundant dibenzocyclooctadiene isolated from the fruit of Schisandra chinensis (Turcz) Baillon or Wu-Wei-Zi (transliterally meaning "the fruit of five tastes" in Chinese), which is a commonly used tonic herb in Chinese medicine, particularly for the treatment of liver ailments.
A11586

Torin 2

mTOR inhibitor
Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
A11605

VE-821

ATM/ATR inhibitor
VE-821 is a potent and selective inhibitor of protein kinase ATR.
A13289

VE-822

ATR inhibitor
VE-822 is an potent ATR inhibitor.
A11161

Wortmannin

PI3K inhibitor

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

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