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All 'Bcl-2' Products
15 Item(s)
per page
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A16112 |
A-1155463 |
BCL-XL inhibitor |
A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki ??0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
|
A16190 |
A-1331852 |
BCL-XL inhibitor |
A-1331852 is a potent and BCL-XL-selective inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.
|
A12500 SALE |
ABT-199 (Venetoclax) |
Bcl-2 inhibitor |
ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
|
A10022 SALE |
ABT-263 (Navitoclax) |
Bcl-2 inhibitor |
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .
|
A14795 |
Acetate gossypol |
Bcl-2 Inhibitor |
Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic.
|
A15004 |
AT-101
|
Bcl-2 Inhibitor |
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.
|
A13578 |
AT101 acetic acid |
pan Bcl-2 inhibitor |
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID
|
A13580 |
Bcl-2 Inhibitor |
Bcl-2 Inhibitor |
Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-x in vitro (IC50 =10 uM and 7 uM, respectively).
|
A15821 |
BDA-366 |
Bcl-2 antagonist |
BDA-366 selectively inhibits BCL2, converting it to a cell death inducer.
|
A12743 |
BM-1074 |
Bcl-2/Bcl-xL inhibitor |
BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM.
|
A11988 SALE |
Gambogic acid |
- |
Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
|
A11448 SALE |
HA14-1 |
Bcl-2 inhibitor |
HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2.
|
A10665 SALE |
Obatoclax mesylate (GX15-070) |
Bcl-2 Inhibitor |
Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
|
A12823 |
Sabutoclax |
Bcl-2 inhibitor |
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
|
A10955 |
TW-37 |
Bcl-2 inhibitor |
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
|
15 Item(s)
per page