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Superior BioReagents Supplier

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All 'Bcl-2' Products

Catalog No.	Product Name	Application	Product Information
A16112	A-1155463	BCL-XL inhibitor	A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki ??0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM) Bcl-w Bcl-xL Bcl-2 Mcl-1
A16190	A-1331852	BCL-XL inhibitor	A-1331852 is a potent and BCL-XL-selective inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. Bcl-w Bcl-xL Bcl-2 Mcl-1
A12500 SALE	ABT-199 (Venetoclax)	Bcl-2 inhibitor	ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. Bcl-w Bcl-xL Bcl-2 Mcl-1
A10022 SALE	ABT-263 (Navitoclax) Product Citations (5) TYW Wei ,etc. Aurora A and NF-κB survival pathway drive chemoresistance in acute myeloid leukemia via the TRAF-interacting protein TIFA. Cancer Research, 2016, 77(2), 494-508. M Matsumoto ,etc. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax-and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochemical and biophysical research communications, 2016, 473(2), 490-496. Y Takagi ,etc. SPIB is a novel prognostic factor in diffuse large B‐cell lymphoma that mediates apoptosis via the PI3K‐AKT pathway. Cancer Science, 2016, 107(9), 1270-1280. P Geserick,etc. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell Death and Disease (2014) 5, e1412. Chi-Hung R. Or, etc. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. International Journal of Molecular Sciences 18(1):44 · December 2016	Bcl-2 inhibitor	ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins . Bcl-w Bcl-xL Bcl-2 Mcl-1 BCL2A1
A14795	Acetate gossypol	Bcl-2 Inhibitor	Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic. Bcl-2 Dehydrogenase
A15004	AT-101	Bcl-2 Inhibitor	AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM. Bcl-xL Bcl-2 Mcl-1
A13578	AT101 acetic acid	pan Bcl-2 inhibitor	AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID Bcl-xL Bcl-2 Mcl-1
A13580	Bcl-2 Inhibitor	Bcl-2 Inhibitor	Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-x in vitro (IC50 =10 uM and 7 uM, respectively). Bcl-xL Bcl-2
A15821	BDA-366	Bcl-2 antagonist	BDA-366 selectively inhibits BCL2, converting it to a cell death inducer. Bcl-2 Bcl2-BH4
A12743	BM-1074	Bcl-2/Bcl-xL inhibitor	BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. Bcl-xL Bcl-2
A11988 SALE	Gambogic acid	-	Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Induces apoptosis in several tumor cell lines including T47D cells. Bcl-xL Bcl-2 Mcl-1 Caspase Bfl-1 Bcl-B
A11448 SALE	HA14-1	Bcl-2 inhibitor	HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2. Bcl-2
A10665 SALE	Obatoclax mesylate (GX15-070) Product Citations (2) P Geserick ,etc. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell death & disease, 2014, 5(9), e1412. CHR Or ,etc. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. International Journal of Molecular Sciences, 2016, 18(1), 44.	Bcl-2 Inhibitor	Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Bcl-2 Mcl-1 Bfl-1
A12823	Sabutoclax Product Citations (1) CD Graham ,etc. BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells.. Oncotarget, 2016, 8 (5), 8670-8678..	Bcl-2 inhibitor	Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Bcl-xL Bcl-2 Mcl-1 Bfl-1
A10955	TW-37	Bcl-2 inhibitor	TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1. Bcl-xL Bcl-2 Mcl-1