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All 'Bcl-2' Products

Catalog No.	Product Name	Application	Product Information
A16112	A-1155463	BCL-XL inhibitor	A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki ??0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
A16190	A-1331852	BCL-XL inhibitor	A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.
A12500 SALE	ABT-199 (Venetoclax)	Bcl-2 inhibitor	ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
A10022 SALE	ABT-263 (Navitoclax)	Bcl-2 inhibitor	ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins . Product Citations (5) Lee JS ,etc. Harnessing synthetic lethality to predict the response to cancer treatment. Nat Commun. 2018 Jun 29;9(1):2546. TYW Wei ,etc. Aurora A and NF-κB survival pathway drive chemoresistance in acute myeloid leukemia via the TRAF-interacting protein TIFA. Cancer Research, 2016, 77(2), 494-508. M Matsumoto ,etc. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax-and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochemical and biophysical research communications, 2016, 473(2), 490-496. Y Takagi ,etc. SPIB is a novel prognostic factor in diffuse large B‐cell lymphoma that mediates apoptosis via the PI3K‐AKT pathway. Cancer Science, 2016, 107(9), 1270-1280. P Geserick,etc. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell Death and Disease (2014) 5, e1412.
A14795	Acetate gossypol	Bcl-2 Inhibitor	Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic.
A15004	AT-101	Bcl-2 Inhibitor	AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.
A13578	AT101 acetic acid	pan Bcl-2 inhibitor	AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID
A13580	Bcl-2 Inhibitor	Bcl-2 Inhibitor	Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively).
A15821	BDA-366	Bcl-2 antagonist	BDA-366 selectively inhibits BCL2, converting it to a cell death inducer.
A12743	BM-1074	Bcl-2/Bcl-xL inhibitor	BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM.
A11988 SALE	Gambogic acid	Bcl-2 inhibitor	Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
A11448 SALE	HA14-1	Bcl-2 inhibitor	HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2.
A10665 SALE	Obatoclax mesylate (GX15-070)	Bcl-2 Inhibitor	Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Product Citations (3) P Geserick ,etc. The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin. Cell death & disease, 2014, 5(9), e1412. CHR Or ,etc. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. International Journal of Molecular Sciences, 2016, 18(1), 44. Chi-Hung R. Or, etc. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. International Journal of Molecular Sciences 18(1):44 · December 2016
A12823	Sabutoclax	Bcl-2 inhibitor	Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Product Citations (1) CD Graham ,etc. BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells.. Oncotarget, 2016, 8 (5), 8670-8678..
A10955	TW-37	Bcl-2 inhibitor	TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.