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All 'DHFR' Products



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Catalog No. Product Name Application Product Information
A10021 SALE

Methotrexate (Abitrexate)

DHFR inhibitor
Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
A10707 SALE

Pemetrexed (Alimta)

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Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
A15207

Pemetrexed disodium hemipenta hydrate

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Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
A11522 SALE

Pralatrexate

DHFR inhibitor
Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells.

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