All 'MEK2' Products



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Catalog No. Product Name Application Product Information
A10089

AS703026 (Pimasertib)

MEK1/2 inhibitor
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
A10115

AZD8330

MEK Inhibitor
AZD8330 is a MEK inhibitor that specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
A15762

BI-847325

MEK/Aurora Inhibitor
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
A11029

GSK1120212 (JTP-74057, Trametinib)

MEK Inhibitor
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
A10212

PD184352 (CI-1040)

MKK/MEK inhibitor
PD184352 is a MEK inhibitor (IC50 = 10-100 nM), a kinase upstream in the mitogen-activated protein kinase pathway (MAPK).
A10704

PD318088

MEK Inhibitor
PD318088 is an inhibitor of MEK1 AND MEK2.
A11264

Refametinib

MEK inhibitor
Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

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