All 'Smoothened' Products



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Catalog No. Product Name Application Product Information
A13204 SALE

BMS-833923 (XL-139)

Smoothened inhibitor
BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity.
A10249

Cyclopamine

Hedgehog signaling inhibitor
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
A10520 SALE

LDE225 (NVP-LDE225)

Smo Antagonist
LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
A11048 SALE

LY2940680 (Taladegib)

SMO Antagonist
LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
A16111

MK-4101

Hedgehog inhibitor
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
A13881

PF-04449913

Smoothened inhibitor
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.
A12775

PF-5274857

Smoothened Inhibitor
PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.
A11480 SALE

Purmorphamine

Hedgehog signaling activator
Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.
A13095 SALE

SANT-1

Sonic hedgehog inhibitor
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).

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