TAM Receptor

Inhibitory Selectivity
Catalog No.Inhibitor Name MerAxlTyro3Other
A10996Cabozantinib
***
A10153BMS-777607
**
****
****
VEGFR2/KDR,c-Met,Kit
A13741R428
**
RON,Met,FLT3
A14143UNC2250
****
*
VEGFR2/KDR,c-Met,Kit
A15904UNC2025
****
**
**
A15776TP-0903
**
FLT3
A15917NPS-1034
***
A13003LDC1267
***
*
***
Met
A14276UNC2881
****
*
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10996 SALE

XL184 free base (Cabozantinib)

VEGFR inhibitor
XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2.
A15864

SGI-7079

Axl inhibitor
SGI-7079 ,a novel selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.
A15776 SALE

TP-0903

AXL Inhibitor
TP-0903 is a potent and selective Axl kinase inhibitor with IC50 of 27 nM.
A16257

Glesatinib hydrochloride

MET/Axl inhibitor
Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered.
A14411

Gilteritinib (ASP2215)

FLT3/Axl inhibitor
Gilteritinib is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.
A13741 SALE

R428

Axl Inhibitor
R428 is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer.
A10153 SALE

BMS-777607

c-Met inhibitor
BMS-777607 is a MET tyrosine kinase inhibitor that binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
A14276 SALE

UNC2881

Mer tyrosine kinase inhibitor
UNC2881 is a specific Mer tyrosine kinase inhibitor
A14143

UNC 2250

Selective Mer Kinase inhibitor
UNC2250 is a potent and selective Mer Kinase inhibitor.
A13003 SALE

LDC1267

TAM Receptor inhibitor
LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively.
A15917

NPS-1034

c-Met inhibitor
NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
A13805

UNC569

Mer Inhibitor
UNC569 is a novel small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. UNC569 is the first small-molecule Mer inhibitor. UNC569 inhibited Mer activation and downstream signaling through ERK1/2 and AKT.

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