Thapsigargin

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Catalog No. A14007

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Thapsigargin 5mg A14007-5
$150.00
Thapsigargin 10mg A14007-10
$250.00
Thapsigargin 25mg A14007-25
$500.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50=30 nM).

Thapsigargin

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Chemical Information

Catalog Num A14007
Actions N/A
M. Wt 650.75
Formula C34H50O12
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 67526-95-8
Synonyms N/A
SMILES code CCCCCCCC(=O)O[[email protected]]1[[email protected]]2C(=C([[email protected]@H]1OC(=O)/C(=C\C)/C)C)[[email protected]]3[[email protected]]([[email protected]](C[[email protected]]2(C)OC(=O)C)OC(=O)CCC)([[email protected]](C(=O)O3)(C)O)O
Chemical Name (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate

Biological Activity

Description
Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50=30 nM).

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