UNC-1999

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EZH2/EZH1 Inhibitor

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Catalog No. A13166

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
UNC-1999 5mg A13166-5

Regular Price: $60.00

Special Price: $48.00

UNC-1999 10mg A13166-10

Regular Price: $110.00

Special Price: $88.00

UNC-1999 25mg A13166-25

Regular Price: $220.00

Special Price: $176.00

UNC-1999 50mg A13166-50

Regular Price: $350.00

Special Price: $280.00

UNC-1999 10mM * 1mL in DMSO A13166-10mM-D

Regular Price: $127.00

Special Price: $101.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

UNC1999 is the first orally bioavailable inhibitor that has high in vitro potency for wildtype and mutant EZH2 as well as EZH1.

UNC-1999

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Chemical Information

Catalog Num A13166
Actions Inhibitor
M. Wt 569.74
Formula C33H43N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1431612-23-5
Synonyms UNC 1999, UNC1999
SMILES code CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C
Chemical Name 1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

Biological Activity

Description
UNC1999 is the first orally bioavailable inhibitor that has high in vitro potency for wildtype and mutant EZH2 as well as EZH1.
Targets
EZH2 (Cell-free assay) EZH1 (Cell-free assay)
2 nM45 nM

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL (175.51 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (175.51 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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