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- Daniel Gundel, .et al. Preclinical Evaluation of [18F]FACH in Healthy Mice and Piglets: An 18F-Labeled Ligand for Imaging of Monocarboxylate Transporters with PET, Int J Mol Sci, 2021, Feb; 22(4): 1645 PMID: 33562048
Biological Activity
7ACC1 selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.
| In vitro | DMSO | 45 mg/mL (172.23 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 38.27 mL | 191.37 mL | 382.75 mL |
| 0.5 mM | 7.65 mL | 38.27 mL | 76.55 mL |
| 1 mM | 3.83 mL | 19.14 mL | 38.27 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.65 mL |
*The above data is based on the productmolecular weight 261.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15810 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 50995-74-9 |
| Formula | C14H15NO4 |
| M. Wt | 261.27 |
| Purity | >98% |
| Synonyms | DEAC, Coumarin D 1421, D 1421 |
| SMILES | CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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