A66

Catalog No.: A11202

PI3K inhibitor

A66

A66 Chemical Structure

CAS NO. 1166227-08-2

The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA).

Availability: In stock

Package Price Qty
5 mg
$85.00
10 mg
$140.00
50 mg
$485.00
100 mg
$700.00
10mM * 1mL in DMSO
$120.00
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Biological Activity

The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA).
In vitro (25°C) DMSO 77 mg/mL (195.66 mM)
Water Insoluble
Ethanol 1 mg/mL (2.54 mM)
In vivo 15% Captisol 7 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.41 mL 127.06 mL 254.11 mL
0.5 mM 5.08 mL 25.41 mL 50.82 mL
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11202
Actions Inhibitor
CAS No. 1166227-08-2
Formula C17H23N5O2S2
M. Wt 393.53
Solubility DMSO
Purity >98%
Synonyms A-66
SMILES CC1=C(SC(=N1)NC(=O)N2CCC[[email protected]]2C(=O)N)C3=CSC(=N3)C(C)(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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