AChR

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  1. EVP-6124 hydrochloride

    Catalog No. A15087
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    nAChR Inhibitor
    EVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. Learn More
  2. Bethanechol chloride

    Catalog No. A10180
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    Muscarinic receptor agonist
    Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Learn More
  3. Methoctramine hydrate

    Catalog No. A11975
    Methoctramine hydrate is a selective M2 muscarinic receptor antagonist at nM concentrations Learn More
  4. Irsogladine

    Catalog No. A10480
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    Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. Learn More
  5. Darifenacin

    Catalog No. A11987
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    Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. Learn More
  6. Gallamine triethiodide

    Catalog No. A10417
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    Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. Learn More
  7. Ipratropium bromide

    Catalog No. A10476
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    Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. Learn More
  8. Methscopolamine bromide

    Catalog No. A10579
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    Methscopolamine bromide is a competitive antimuscarinic agent that blocks the binding of acetylcholine at muscarinic acetylcholine receptors (mAChR M). Learn More
  9. Neostigmine bromide (Prostigmin)

    Catalog No. A10635
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    Acetylcholine esterase inhibitor
    Neostigmine bromide is a reversible acetylcholine esterase inhibitor that binds to the anionic binding site of AChE. Learn More
  10. Oxybutynin

    Catalog No. A10684
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    Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties. Learn More
  11. Arecoline

    Catalog No. A13071
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    Arecoline is a cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Learn More
  12. A-582941

    Catalog No. A13539
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    α7 nAChR agonist
    A-582941 is a selective AChR a7 partial agonist. It exhibits high affinity for both rat and human a7 receptors (Ki values are 10.8 and 16.7 nM, respectively). Learn More
  13. Metanicotine

    Catalog No. A11545
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    Nicotinic receptor agonist
    Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the ??4??2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM). Learn More
  14. EVP-6124 (Encenicline)

    Catalog No. A15086
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    nAChR Inhibitor
    EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs); shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. Learn More
  15. Orphenadrine citrate

    Catalog No. A11712
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    Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. Learn More
  16. Tropicamide

    Catalog No. A11706
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    Tropicamide is an anticholinergic used as a mydriatic. Learn More
  17. Rocuronium bromide

    Catalog No. A10803
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    AchR antagonist
    Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia. Learn More
  18. Galanthamine hydrobromide

    Catalog No. A10416
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    Galanthamine is an AChE inhibitor with IC50 of 14 nM. Learn More
  19. PNU-120596

    Catalog No. A11203
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    Nicotinic (α7) Receptor Modulator
    PNU-120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors. Learn More
  20. Biperiden HCl

    Catalog No. A10147
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    Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype Learn More
  21. Tolterodine tartrate (Detrol LA)

    Catalog No. A10937
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    muscarinic receptor antagonist
    Tolterodine tartrate (Detrol LA) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence. Learn More
  22. 5-hydroxymethyl tolterodine (PNU 200577)

    Catalog No. A11166
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    muscarinic receptor antagonist

    5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

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  23. Solifenacin succinate

    Catalog No. A11215
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    muscarinic M3 receptor antagoinst
    Solifenacin-succinate is a muscarinic M3 receptor antagoinst, used in treatment of urinary incontinence. Learn More
  24. PNU 282987

    Catalog No. A11233
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    α7 nAChR agonist
    PNU 282987 (PNU-282,987)is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors. Learn More
  25. Fesoterodine fumarate (Toviaz)

    Catalog No. A10386
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    AChR antagonist
    Fesoterodine fumarate is a medicine which is used in urinary urgency, reducing the frequency of passing urine and urge urinary incontinence Learn More
  26. Rivastigmine tartrate

    Catalog No. A11719
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    ChE inhibitor
    Rivastigmine tartrate is a dual cholinesterase inhibitor (ChEI). It inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Learn More
  27. SVT-40776 (Tarafenacin)

    Catalog No. A10808
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    muscarinic receptor antagonist
    SVT-40776 is a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Learn More
  28. Atropine

    Catalog No. A10098
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    AChR antagonist
    Atropine is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. Learn More
  29. A-867744

    Catalog No. A11290
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    modulator of α7 nAChRs
    A-867744 is a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. Learn More
  30. Flavoxate

    Catalog No. A12900
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    Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. Learn More
  31. TBPB

    Catalog No. A14205
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    M1 mAChR agonist
    TBPB is an allosteric M1 mAChR agonist with EC50 value of 89 nM that regulates amyloid processing and produces antipsychotic-like activity in rats. Learn More
  32. GTS-21 (DMBX-A)

    Catalog No. A15950
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    nAChR agonist
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Learn More
  33. Revefenacin

    Catalog No. A15986
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    muscarinic receptor antagonist
    Revefenacin is potent and selective muscarinic receptor antagonist in development for the treatment of COPD. Learn More
  34. Glycopyrrolate

    Catalog No. A12641
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    muscarinic antagonist
    Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic. Learn More
  35. (-)-Nicotine ditartrate

    Catalog No. A13761
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    (-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto). Learn More
  36. Benzethonium Chloride

    Catalog No. A13653
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    nAChR inhibitor
    Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively. Learn More
  37. (-)-(S)-B-973B

    Catalog No. A18761
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    α7 nAChR modulator
    -)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity. Learn More
  38. BNC375

    Catalog No. A18503
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    α7 nAChR Modulator
    BNC375 is a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. Learn More
  39. Cimetropium Bromide

    Catalog No. A18290
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    mAChR antagonist
    Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome. Learn More
  40. Anisodamine

    Catalog No. A18215
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    alpha-1 adrenergic receptors / mAChRs inhibitor
    Anisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant. Learn More
  41. Cevimeline hydrochloride

    Catalog No. A18092
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    mAChR agonist
    Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. Learn More
  42. Atropine methyl bromide

    Catalog No. A18026
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    mAChR antagonist
    Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine. Learn More
  43. Mecamylamine Hydrochloride

    Catalog No. A17884
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    nAChR antagonist
    Mecamylamine hydrochloride is a nAChR antagonist previously used to treat hypertension. It displays a wide variety of activities, including reducing depression-like behaviors in subjects with Tourette's syndrome and improving rates of smoking cessation. Learn More
  44. Acetylcholine iodide

    Catalog No. A16390
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    Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. Learn More
  45. Imidafenacin

    Catalog No. A15490
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    M3 receptors inhibitor
    Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). Learn More
  46. Umeclidinium bromide

    Catalog No. A15268
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    Muscarinic receptor antagonist
    Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD). Learn More
  47. Adiphenine HCl

    Catalog No. A11716
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    AChR inhibitor
    Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug Learn More
  48. Methyllycaconitine citrate

    Catalog No. A12681
    Methyllycaconitine citrate is a potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Learn More
  49. Catharanthine sulfate

    Catalog No. A12161
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    Catharanthine sulfate is a vinblastine-type alkaloid precursor with antitumor activity. It inhibits AChR by ion channel blocking and desensitization. Learn More
  50. Ispronicline (TC-1734, AZD-3480)

    Catalog No. A14183
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    nAChR agonist
    Ispronicline is a neuronal nicotinic acetylcholine receptor partial agonist. Ispronicline is subtype-selective, binding primarily to the a4b2 subtype. It has antidepressant, nootropic and neuroprotective effects. Learn More

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