AChR

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  1. Metanicotine

    Catalog No. A11545
    Nicotinic receptor agonist
    Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the ??4??2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM). Learn More
  2. Methoctramine hydrate

    Catalog No. A11975
    Methoctramine hydrate is a selective M2 muscarinic receptor antagonist at nM concentrations Learn More
  3. Irsogladine

    Catalog No. A10480
    Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. Learn More
  4. Darifenacin

    Catalog No. A11987
    Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. Learn More
  5. Gallamine triethiodide

    Catalog No. A10417
    Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. Learn More
  6. Ipratropium bromide

    Catalog No. A10476
    Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. Learn More
  7. Methscopolamine bromide

    Catalog No. A10579
    Methscopolamine bromide is a competitive antimuscarinic agent that blocks the binding of acetylcholine at muscarinic acetylcholine receptors (mAChR M). Learn More
  8. Acetylcholine esterase inhibitor
    Neostigmine bromide is a reversible acetylcholine esterase inhibitor that binds to the anionic binding site of AChE. Learn More
  9. Oxybutynin

    Catalog No. A10684
    Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties. Learn More
  10. Arecoline

    Catalog No. A13071
    Arecoline is a cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Learn More
  11. A-582941

    Catalog No. A13539
    α7 nAChR agonist
    A-582941 is a selective AChR a7 partial agonist. It exhibits high affinity for both rat and human a7 receptors (Ki values are 10.8 and 16.7 nM, respectively). Learn More
  12. EVP-6124 (Encenicline)

    Catalog No. A15086
    nAChR Inhibitor
    EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs); shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. Learn More
  13. EVP-6124 hydrochloride

    Catalog No. A15087
    nAChR Inhibitor
    EVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. Learn More
  14. Bethanechol chloride

    Catalog No. A10180
    Muscarinic receptor agonist
    Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Learn More
  15. Orphenadrine citrate

    Catalog No. A11712
    Orphenadrine is known to have the following pharmacology: mACh receptor antagonist (anticholinergic); H1 receptor antagonist (antihistamine); NMDA receptor antagonist; NET blocker (norepinephrine reuptake inhibitor); Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker; HERG potassium channel blocker. Learn More
  16. Tropicamide

    Catalog No. A11706
    Tropicamide is an anticholinergic used as a mydriatic. Learn More
  17. AChR antagonist
    Fesoterodine fumarate is a medicine which is used in urinary urgency, reducing the frequency of passing urine and urge urinary incontinence Learn More
  18. muscarinic receptor antagonist

    5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

    Learn More
  19. PNU-120596

    Catalog No. A11203
    Nicotinic (α7) Receptor Modulator
    PNU-120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors. Learn More
  20. PNU 282987

    Catalog No. A11233
    α7 nAChR agonist
    PNU 282987 (PNU-282,987)is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors. Learn More
  21. Rocuronium bromide

    Catalog No. A10803
    AchR antagonist
    Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia. Learn More
  22. Galanthamine hydrobromide

    Catalog No. A10416
    Galanthamine is an AChE inhibitor with IC50 of 14 nM. Learn More
  23. Biperiden HCl

    Catalog No. A10147
    Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype Learn More
  24. muscarinic receptor antagonist
    Tolterodine tartrate (Detrol LA) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence. Learn More
  25. Rivastigmine tartrate

    Catalog No. A11719
    ChE inhibitor
    Rivastigmine tartrate is a dual cholinesterase inhibitor (ChEI). It inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Learn More
  26. SVT-40776 (Tarafenacin)

    Catalog No. A10808
    muscarinic receptor antagonist
    SVT-40776 is a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Learn More
  27. Atropine

    Catalog No. A10098
    AChR antagonist
    Atropine is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. Learn More
  28. A-867744

    Catalog No. A11290
    modulator of α7 nAChRs
    A-867744 is a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. Learn More
  29. Solifenacin succinate

    Catalog No. A11215
    muscarinic M3 receptor antagoinst
    Solifenacin-succinate is a muscarinic M3 receptor antagoinst, used in treatment of urinary incontinence. Learn More
  30. PF-3635659

    Catalog No. A13548
    muscarinic M(3) receptor antagonist
    PF-3635659 is a potent muscarinic M(3) receptor antagonist. Learn More
  31. M1 agonist
    Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. Learn More
  32. Umeclidinium bromide

    Catalog No. A15268
    Muscarinic receptor antagonist
    Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD). Learn More
  33. Imidafenacin

    Catalog No. A15490
    M3 receptors inhibitor
    Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). Learn More
  34. (-)-Nicotine ditartrate

    Catalog No. A13761
    (-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto). Learn More
  35. TBPB

    Catalog No. A14205
    M1 mAChR agonist
    TBPB is an allosteric M1 mAChR agonist with EC50 value of 89 nM that regulates amyloid processing and produces antipsychotic-like activity in rats. Learn More
  36. GTS-21 (DMBX-A)

    Catalog No. A15950
    nAChR agonist
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Learn More
  37. Revefenacin

    Catalog No. A15986
    muscarinic receptor antagonist
    Revefenacin is potent and selective muscarinic receptor antagonist in development for the treatment of COPD. Learn More
  38. Glycopyrrolate

    Catalog No. A12641
    muscarinic antagonist
    Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic. Learn More
  39. Flavoxate

    Catalog No. A12900
    Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. Learn More
  40. Benzethonium Chloride

    Catalog No. A13653
    nAChR inhibitor
    Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively. Learn More
  41. 5-Iodo-A-85380 2HCl

    Catalog No. A13639
    nAChR agonist
    5-Iodo-A-85380 2HCl is a highly potent and subtype-selective agonist for the a4b2 and a6b2 nicotinic acetylcholine receptors. Learn More
  42. ABT-418 HCl

    Catalog No. A13688
    nAChR agonist
    ABT-418 HCl is a neuronal nicotinic acetylcholine receptor agonist. Learn More
  43. Xanomeline oxalate

    Catalog No. A13685
    mAChR agonist
    Xanomeline oxalate is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively). Learn More
  44. Varenicline

    Catalog No. A10966
    Varenicline is a nicotinic receptor partial agonist. Learn More
  45. Adiphenine HCl

    Catalog No. A11716
    AChR inhibitor
    Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug Learn More
  46. Methyllycaconitine citrate

    Catalog No. A12681
    Methyllycaconitine citrate is a potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Learn More
  47. Catharanthine sulfate

    Catalog No. A12161
    Catharanthine sulfate is a vinblastine-type alkaloid precursor with antitumor activity. It inhibits AChR by ion channel blocking and desensitization. Learn More
  48. nAChR agonist
    Ispronicline is a neuronal nicotinic acetylcholine receptor partial agonist. Ispronicline is subtype-selective, binding primarily to the a4b2 subtype. It has antidepressant, nootropic and neuroprotective effects. Learn More
  49. LY2119620

    Catalog No. A14217
    M2/M4 AChR agonist
    LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. Learn More
  50. Diphenidol HCl

    Catalog No. A14244
    M2/M3 antagonist
    Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02. Learn More

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