E1 activating

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  1. TAK-981

    Catalog No. A20002
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    SUMO inhibitor
    TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities. Learn More
  2. PYR-41

    Catalog No. A13254
    Ubiquitin E1 Inhibitor
    PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Learn More
  3. 2-D08

    Catalog No. A16852
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    SUMO inhibitor
    2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. Learn More
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    COH000

    Catalog No. A17122
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    SUMO E1 Inhibitor
    COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro. Learn More

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