ADX-47273

Catalog No.: A11181

mGluR5 modulator

ADX-47273

ADX-47273 Chemical Structure

CAS NO. 851881-60-2

ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$80.00
50 mg
$290.00
100 mg
$520.00
10mM * 1mL in DMSO
$55.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.

Targets
mGlu5
0.17 μM(EC50)
In vitro (25°C) DMSO 73 mg/mL (197.63 mM)
Water Insoluble
Ethanol 29 mg/mL (78.51 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.07 mL 135.37 mL 270.74 mL
0.5 mM 5.41 mL 27.07 mL 54.15 mL
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL

*The above data is based on the productmolecular weight 369.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11181
Actions Modulator
CAS No. 851881-60-2
Formula C20H17F2N3O2
M. Wt 369.36
Purity >98%
Synonyms ADX47273
SMILES C1C[[email protected]@H](CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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