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AEE788

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EGFR inhibitor

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Catalog No. A10043

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AEE788 5mg A10043-5

Regular Price: €85.50

Special Price: €76.95

AEE788 10mg A10043-10

Regular Price: €152.00

Special Price: €136.80

AEE788 25mg A10043-25

Regular Price: €304.00

Special Price: €273.60

AEE788 50mg A10043-50

Regular Price: €522.50

Special Price: €470.25

AEE788 10mM * 1mL in DMSO A10043-10mM-D

Regular Price: €156.75

Special Price: €141.08

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.

AEE788

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Chemical Information

Catalog Num A10043
Actions Inhibitor
M. Wt 440.6
Formula C27H32N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 497839-62-0
Synonyms AEE-788, NVP-AEE788
SMILES code CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4N[[email protected]](C)C5=CC=CC=C5
Chemical Name 6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Biological Activity

Description
 AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.
Targets
Target Value
EGFRIC50: 2nM
HER2/ErbB2IC50: 6nM
c-AblIC50: 52nM
FLT1IC50: 59nM
c-FmsIC50: 60nM
c-SrcIC50: 61nM
KDRIC50: 77nM
HER4/ErbB4IC50: 160nM
PDGFRβIC50: 320nM
FLT4IC50: 330nM
FLT3IC50: 730nM
RETIC50: 740nM
c-KitIC50: 790nM
TekIC50: 2.1μM
C-Raf-1IC50: 2.8μM
c-MetIC50: 2.9μM
CDK1/CyclinBIC50: 8.0μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
PKCαIC50: >10μM
PKAIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 88 mg/mL (199.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.48 mL 226.96mL
0.5 mM 4.54 mL 22.7 mL 45.39 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Related Products

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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