AEE788

Name: AEE788
Brand: Adooq Bioscience
SKU: A10043
Rating: 100 (268 reviews)

Catalog No.: A10043

EGFR inhibitor

AEE788 Chemical Structure

CAS NO. 497839-62-0

AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$160.00
25 mg	$320.00
50 mg	$550.00
10mM * 1mL in DMSO	$165.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.

Targets

Target	Value
EGFR	IC50: 2nM
HER2/ErbB2	IC50: 6nM
c-Abl	IC50: 52nM
FLT1	IC50: 59nM
c-Fms	IC50: 60nM
c-Src	IC50: 61nM
KDR	IC50: 77nM
HER4/ErbB4	IC50: 160nM
PDGFRβ	IC50: 320nM
FLT4	IC50: 330nM
FLT3	IC50: 730nM
RET	IC50: 740nM
c-Kit	IC50: 790nM
Tek	IC50: 2.1μM
C-Raf-1	IC50: 2.8μM
c-Met	IC50: 2.9μM
CDK1/CyclinB	IC50: 8.0μM
IGF-1R	IC50: >10μM
Insulin Receptor	IC50: >10μM
PKCα	IC50: >10μM
PKA	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	81 mg/mL (183.84 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.7 mL	113.48 mL	226.96 mL
0.5 mM	4.54 mL	22.7 mL	45.39 mL
1 mM	2.27 mL	11.35 mL	22.7 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

*The above data is based on the productmolecular weight 440.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10043
Actions	Inhibitor
CAS No.	497839-62-0
Formula	C27H32N6
M. Wt	440.6
Purity	>98%
Synonyms	AEE-788, NVP-AEE788
SMILES	CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4N[[email protected]](C)C5=CC=CC=C5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.