AGI-5198 (IDH-C35)

Catalog No.: A12902

IDH1 inhibitor

AGI-5198 (IDH-C35)

AGI-5198 (IDH-C35) Chemical Structure

CAS NO. 1355326-35-0

AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.

Availability: In stock

Package Price Qty
10 mg
$46.00
25 mg
$81.00
50 mg
$135.00
10mM * 1mL in DMSO
$170.00
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Biological Activity

AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.
Targets
R132H-IDH1 R132C-IDH1
70 nM0.16 μM
In vitro (25°C) DMSO 22 mg/mL (47.56 mM)
Water Insoluble
Ethanol 13 mg/mL (28.1 mM)
In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.62 mL 108.09 mL 216.19 mL
0.5 mM 4.32 mL 21.62 mL 43.24 mL
1 mM 2.16 mL 10.81 mL 21.62 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 462.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12902
Actions Inhibitor
CAS No. 1355326-35-0
Formula C27H31FN4O2
M. Wt 462.56
Purity >98%
Synonyms AGI5198,AGI 5198, IDHC35
SMILES CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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