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$0.00 - Tomoya Takeda, .et al. AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor-sensitive and -resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B, Oncol Rep, 2020, August 18
Biological Activity
AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Targets
| Target | Value |
|---|---|
| AuroraC | IC50: 1nM |
| AuroraB | IC50: 4nM |
| AuroraA | IC50: 5nM |
| p38α | IC50: 53nM |
| TYK2 | IC50: 220nM |
| JNK2 | IC50: 520nM |
| Met | IC50: 550nM |
| Tie-2 | IC50: 650nM |
| In vitro (25°C) | DMSO | 90 mg/mL (178.71 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.86 mL | 99.29 mL | 198.57 mL |
| 0.5 mM | 3.97 mL | 19.86 mL | 39.71 mL |
| 1 mM | 1.99 mL | 9.93 mL | 19.86 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.97 mL |
*The above data is based on the productmolecular weight 503.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11066 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 945595-80-2 |
| Formula | C28H21N7OS |
| M. Wt | 503.6 |
| Purity | >98% |
| Synonyms | AMG-900, AMG900 |
| SMILES | CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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