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Biological Activity
Anacetrapib (MK-0859) is a CETP inhibitor being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease.
| In vitro (25°C) | DMSO | 108 mg/mL (169.41 mM) | |
| Water | Insoluble | ||
| Ethanol | 108 mg/mL (169.41 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.69 mL | 78.43 mL | 156.86 mL |
| 0.5 mM | 3.14 mL | 15.69 mL | 31.37 mL |
| 1 mM | 1.57 mL | 7.84 mL | 15.69 mL |
| 5 mM | 0.31 mL | 1.57 mL | 3.14 mL |
*The above data is based on the productmolecular weight 637.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11084 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 875446-37-0 |
| Formula | C30H25F10NO3 |
| M. Wt | 637.5 |
| Purity | >98% |
| Synonyms | MK0859 |
| SMILES | C[[email protected]]1[[email protected]](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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