Apoptosis Inducers

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  1. 14-3-3 protein Inhibitor

    Difopein, dimeric version of R18 peptide that binds to 14.3.3 proteins with high affinity.
  2. inhibitor of tubulin polymerization

    4-Oxo-4-HPR is an inhibitor of tubulin polymerization, inducing marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. It is also a fenretinide metabolite.

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