AS-604850

Catalog No.: A11197
PI3K Inhibitor

AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

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Product Name Price Stock Qty
AS-604850 5mg
Special Price $36.00 Regular Price $45.00
In stock
AS-604850 10mg
Special Price $64.00 Regular Price $80.00
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AS-604850 50mg
Special Price $176.00 Regular Price $220.00
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AS-604850 100mg
Special Price $320.00 Regular Price $400.00
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AS-604850 10mM * 1mL in DMSO
Special Price $74.40 Regular Price $93.00
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Biological Activity
Discription

AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

Targets
Target Value
Product Information
Catalog Num A11197
Formula C11H5F2NO4S
Molecular Weight 285.22
CAS Number 648449-76-7
SMILES C1=CC2=C(C=C1/C=C\3/C(=O)NC(=O)S3)OC(O2)(F)F
Synonyms AS604850
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 49 mg/mL (171.79 mM)
Water Insoluble
Ethanol 4 mg/mL (14.02 mM)
In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.06 mL 175.3 mL 350.61 mL
0.5 mM 7.01 mL 35.06 mL 70.12 mL
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
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