AS-604850

Catalog No.: A11197

PI3K Inhibitor

AS-604850

AS-604850 Chemical Structure

CAS NO. 648449-76-7

AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

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5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $100.00

Special Price $80.00

50 mg

Regular Price: $420.00

Special Price $336.00

100 mg

Regular Price: $620.00

Special Price $496.00

10mM * 1mL in DMSO

Regular Price: $93.00

Special Price $74.40

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Biological Activity

AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

In vitro (25°C) DMSO 49 mg/mL (171.79 mM)
Water Insoluble
Ethanol 4 mg/mL (14.02 mM)
In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.06 mL 175.3 mL 350.61 mL
0.5 mM 7.01 mL 35.06 mL 70.12 mL
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL

*The above data is based on the productmolecular weight 285.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11197
Actions Inhibitor
CAS No. 648449-76-7
Formula C11H5F2NO4S
M. Wt 285.22
Purity >98%
Synonyms AS604850
SMILES C1=CC2=C(C=C1/C=C\3/C(=O)NC(=O)S3)OC(O2)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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