Asenapine maleate

Catalog No.: A10091

H1 antagonist

Asenapine maleate Chemical Structure

CAS NO. 85650-56-2

Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors.

Availability: In stock

Package Price Qty
25 mg
$80.00
50 mg
$100.00
100 mg
$150.00
200 mg
$250.00
10mM * 1mL in DMSO
$72.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors.
Targets
Target Value
5-HT2Cpki: 10.46
5-HT2Apki: 10.15
5-HT7pki: 9.94
5-HT2Bpki: 9.75
5-HT6pki: 9.6
α2B-adrenergicreceptorpki: 9.49
D3receptorpki: 9.38
H1receptorpki: 9
D4receptorpki: 8.95
α1A-adrenergicreceptorpki: 8.93
α2C-adrenergicreceptorpki: 8.91
D2LReceptorpki: 8.9
α2A-adrenergicreceptorpki: 8.9
D1receptorpki: 8.85
5-HT5Apki: 8.84
D2SReceptorpki: 8.84
5-HT1Apki: 8.6
5-HT1Bpki: 8.4
H2receptorpki: 8.21
In vitro DMSO 80 mg/mL (199.08 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.89 mL 124.43 mL 248.86 mL
0.5 mM 4.98 mL 24.89 mL 49.77 mL
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL

*The above data is based on the productmolecular weight 401.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10091
Actions Antagonist
M. Wt 401.84
Formula C17H16ClNO.C4H4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 85650-56-2
Synonyms N/A
SMILES CN1C[[email protected]]2[[email protected]](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

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