AT-406 (SM-406, ARRY-334543)

Name: AT-406 (SM-406, ARRY-334543)
Brand: Adooq Bioscience
SKU: A11163
Rating: 100 (2 reviews)

Catalog No.: A11163

IAP inhibitor

Product Citations (2)

AT-406 (SM-406, ARRY-334543) Chemical Structure

CAS NO. 1071992-99-8

AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

Availability: In stock

Package	Price	Qty
5 mg	$120.00
10 mg	$160.00
50 mg	$620.00
200 mg	$1,980.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq AT-406 (SM-406, ARRY-334543)

Yoshikawa M, .et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships, J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864
Tsuyoshi Ishii, .et al. CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens, Sci Rep, 2017, 7: 13000 PMID: 29026104

Biological Activity

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (151.32 mM)
	Water	Insoluble
	Ethanol	85 mg/mL (151.32 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.8 mL	89.01 mL	178.03 mL
0.5 mM	3.56 mL	17.8 mL	35.61 mL
1 mM	1.78 mL	8.9 mL	17.8 mL
5 mM	0.36 mL	1.78 mL	3.56 mL

*The above data is based on the productmolecular weight 561.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11163
Actions	Inhibitor
CAS No.	1071992-99-8
Formula	C32H43N5O4
M. Wt	561.71
Purity	>98%
Synonyms	AT406, SM-406, ARRY-334543
SMILES	C[[email protected]@H](C(=O)N[[email protected]]1CN(CC[[email protected]]2CC[[email protected]](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.