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- Yoshikawa M, .et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships, J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864
- Tsuyoshi Ishii, .et al. CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens, Sci Rep, 2017, 7: 13000 PMID: 29026104
Biological Activity
AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).
In vitro (25°C) | DMSO | 85 mg/mL (151.32 mM) | |
Water | Insoluble | ||
Ethanol | 85 mg/mL (151.32 mM) | ||
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.8 mL | 89.01 mL | 178.03 mL |
0.5 mM | 3.56 mL | 17.8 mL | 35.61 mL |
1 mM | 1.78 mL | 8.9 mL | 17.8 mL |
5 mM | 0.36 mL | 1.78 mL | 3.56 mL |
*The above data is based on the productmolecular weight 561.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11163 |
---|---|
Actions | Inhibitor |
CAS No. | 1071992-99-8 |
Formula | C32H43N5O4 |
M. Wt | 561.71 |
Purity | >98% |
Synonyms | AT406, SM-406, ARRY-334543 |
SMILES | C[[email protected]@H](C(=O)N[[email protected]]1CN(CC[[email protected]]2CC[[email protected]](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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