Onalespib (AT13387)

Catalog No.: A11062

HSP90 Inhibitor

Onalespib (AT13387)

Onalespib (AT13387) Chemical Structure

CAS NO. 912999-49-6

AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
50 mg
$350.00
100 mg
$570.00
10mM * 1mL in DMSO
$95.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Boucherat O, .et al. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Respir Crit Care Med, 2018, Jul 1;198(1):90-103 PMID: 29394093
  • Olivier Boucherat, .et al. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension, Sci Rep, 2017, 7: 4546 PMID: 28674407
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.
Targets
HSP90 (Cell-free assay)
18 nM
In vitro (25°C) DMSO 22 mg/mL (53.72 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+ddH2O (prepare before use) 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.1 mL 244.2 mL
0.5 mM 4.88 mL 24.42 mL 48.84 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11062
Actions Inhibitor
CAS No. 912999-49-6
Formula C24H31N3O3
M. Wt 409.5
Purity >98%
Synonyms AT-13387
SMILES CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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