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Onalespib (AT13387)

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HSP90 Inhibitor

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Catalog No. A11062

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT13387 5mg A11062-5

Regular Price: $90.00

Special Price: $81.00

AT13387 10mg A11062-10

Regular Price: $150.00

Special Price: $135.00

AT13387 50mg A11062-50

Regular Price: $350.00

Special Price: $315.00

AT13387 100mg A11062-100

Regular Price: $570.00

Special Price: $513.00

AT13387 10mM * 1mL in DMSO A11062-10mM-D

Regular Price: $95.00

Special Price: $85.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.

Onalespib (AT13387)

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Publications citing Adooq Products
Onalespib (AT13387) Citations (3)
  • Boucherat O, .et al. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Respir Crit Care Med, 2018, Jul 1;198(1):90-103 PMID: 29394093
  • Olivier Boucherat, .et al. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension, Sci Rep, 2017, 7: 4546 PMID: 28674407
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Chemical Information

Catalog Num A11062
Actions Inhibitor
M. Wt 409.5
Formula C24H31N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 912999-49-6
Synonyms AT-13387
SMILES CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O

Biological Activity

Description
AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.
Targets
HSP90 (Cell-free assay)
18 nM

Solubility

Solubility (25°C) * In vitro DMSO 25 mg/mL (61.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.1 mL 244.2mL
0.5 mM 4.88 mL 24.42 mL 48.84 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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