TC-S 7010 (Aurora A Inhibitor I)

Catalog No.: A10100

Aurora A Inhibitor

TC-S 7010 (Aurora A Inhibitor I)

TC-S 7010 (Aurora A Inhibitor I) Chemical Structure

CAS NO. 1158838-45-9

Aurora A Inhibitor I is a potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.

Availability: Out of stock

Package Price
5 mg
$60.00
10 mg
$110.00
50 mg
$380.00
100 mg
$600.00
10mM * 1mL in DMSO
$97.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Aurora A Inhibitor I is a potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.

Targets
Aurora A (Cell-free assay) Aurora C (Cell-free assay) Aurora B (Cell-free assay)
3.4 nM432 nM3.4 μM
In vitro (25°C) DMSO 105 mg/mL (178.54 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 1.18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17 mL 85.02 mL 170.04 mL
0.5 mM 3.4 mL 17 mL 34.01 mL
1 mM 1.7 mL 8.5 mL 17 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 588.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10100
Actions Inhibitor
CAS No. 1158838-45-9
Formula C31H31ClFN7O2
M. Wt 588.1
Purity >98%
Synonyms TC-S7010, TC-S-7010, TCS7010, TCS-7010
SMILES CCN1CCN(CC1)C(=O)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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