Biological Activity
Aurora A Inhibitor I is a potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.
Targets
Aurora A (Cell-free assay) | Aurora C (Cell-free assay) | Aurora B (Cell-free assay) | ||
3.4 nM | 432 nM | 3.4 μM |
In vitro | DMSO | 118 mg/mL (200.65 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17 mL | 85.02 mL | 170.04 mL |
0.5 mM | 3.4 mL | 17 mL | 34.01 mL |
1 mM | 1.7 mL | 8.5 mL | 17 mL |
5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 588.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10100 |
---|---|
Actions | Inhibitor |
M. Wt | 588.1 |
Formula | C31H31ClFN7O2 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1158838-45-9 |
Synonyms | TC-S7010, TC-S-7010, TCS7010, TCS-7010 |
SMILES | CCN1CCN(CC1)C(=O)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)F |
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