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AZD8330

AZD8330

Name: AZD8330
Brand: Adooq Bioscience
SKU: A10115
Rating: 100 (268 reviews)

Catalog No.: A10115

MEK Inhibitor

AZD8330 Chemical Structure

CAS NO. 869357-68-6

AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.

Availability: In stock

Package	Price	Qty
5 mg	$110.00
10 mg	$200.00
50 mg	$620.00
100 mg	$1,080.00
10mM * 1mL in DMSO	$160.00
Custom Size	Get quote

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Adooq Products cited in reputable paper

Biological Activity

AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.

Targets

ERK phosphorylation	MEK1/2
0.4 nM	7 nM

Solubility *

In vitro (25°C)	DMSO	88 mg/mL (190.79 mM)
	Water	Insoluble
	Ethanol	88 mg/mL (190.79 mM)
In vivo	0.5% hydroxyethyl cellulose+0.1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.68 mL	108.41 mL	216.83 mL
0.5 mM	4.34 mL	21.68 mL	43.37 mL
1 mM	2.17 mL	10.84 mL	21.68 mL
5 mM	0.43 mL	2.17 mL	4.34 mL

*The above data is based on the productmolecular weight 461.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10115
Actions	Inhibitor
CAS No.	869357-68-6
Formula	C16H17FIN3O4
M. Wt	461.2
Purity	>98%
Synonyms	AZD-8330
SMILES	CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.