AZD8931 (Sapitinib)

Catalog No.: A10116

pan-EGFR/pan-erbB inhibitor

AZD8931 (Sapitinib)

AZD8931 (Sapitinib) Chemical Structure

CAS NO. 848942-61-0

AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$80.00
25 mg
$140.00
100 mg
$250.00
10mM * 1mL in DMSO
$60.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Takeshi Ito, .et al. Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification, Biochem Biophys Res Commun, 2019, in Press

Biological Activity

AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.
Targets
ErbB2 (Cell-free assay) EGFR (Cell-free assay) ErbB3 (Cell-free assay)
3 nM4 nM4 nM
In vitro (25°C) DMSO 40 mg/mL (84.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.1 mL 105.51 mL 211.01 mL
0.5 mM 4.22 mL 21.1 mL 42.2 mL
1 mM 2.11 mL 10.55 mL 21.1 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 473.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10116
Actions Inhibitor
M. Wt 473.9
Formula C23H25ClFN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 848942-61-0
Synonyms AZD-8931, Momelotinib, Sapitinib
SMILES CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy AZD8931 (Sapitinib) | AZD8931 (Sapitinib) Supplier | purchase | cost | manufacturer | order | distributor | buy 848942-61-0| 848942-61-0 Supplier | purchase 848942-61-0 | 848942-61-0 cost | 848942-61-0 manufacturer | order 848942-61-0 | 848942-61-0 distributor
Rewards