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AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.
Targets
| ErbB2 (Cell-free assay) | EGFR (Cell-free assay) | ErbB3 (Cell-free assay) | ||
| 3 nM | 4 nM | 4 nM |
| In vitro (25°C) | DMSO | 40 mg/mL (84.4 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.1 mL | 105.51 mL | 211.01 mL |
| 0.5 mM | 4.22 mL | 21.1 mL | 42.2 mL |
| 1 mM | 2.11 mL | 10.55 mL | 21.1 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 473.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A10116 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 473.9 |
| Formula | C23H25ClFN5O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 848942-61-0 |
| Synonyms | AZD-8931, Momelotinib, Sapitinib |
| SMILES | CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC |
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