AZD8931 (Sapitinib)

Catalog No.: A10116

pan-EGFR/pan-erbB inhibitor

AZD8931 (Sapitinib)

AZD8931 (Sapitinib) Chemical Structure

CAS NO. 848942-61-0

AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Takeshi Ito, .et al. Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification, Biochem Biophys Res Commun, 2019, in Press

Biological Activity

AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.
ErbB2 (Cell-free assay) EGFR (Cell-free assay) ErbB3 (Cell-free assay)
3 nM4 nM4 nM
In vitro (25°C) DMSO 37 mg/mL (78.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.1 mL 105.51 mL 211.01 mL
0.5 mM 4.22 mL 21.1 mL 42.2 mL
1 mM 2.11 mL 10.55 mL 21.1 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 473.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10116
Actions Inhibitor
CAS No. 848942-61-0
Formula C23H25ClFN5O3
M. Wt 473.9
Purity >98%
Synonyms AZD-8931, Momelotinib, Sapitinib

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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