BAY 61-3606

Catalog No.: A11320

Syk Inhibitor

BAY 61-3606

BAY 61-3606 Chemical Structure

CAS NO. 732983-37-8

BAY 61-3606 is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

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Package Price Qty
5 mg

Regular Price: $150.00

Special Price $120.00

10 mg

Regular Price: $260.00

Special Price $208.00

25 mg

Regular Price: $520.00

Special Price $416.00

50 mg

Regular Price: $960.00

Special Price $768.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Sojin Park, .et al. BAFF attenuates oxidative stress-induced cell death by the regulation of mitochondria membrane potential via Syk activation in WiL2-NS B lymphoblasts, Sci Rep, 2020, 10: 11784 PMID: 32678160
  • Park S, .et al. Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts, Free Radic Res, 2018, Sep 11:1-11 PMID: 30203714

Biological Activity

BAY 61-3606 is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.61 mL 128.07 mL 256.15 mL
0.5 mM 5.12 mL 25.61 mL 51.23 mL
1 mM 2.56 mL 12.81 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL

*The above data is based on the productmolecular weight 390.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11320
Actions Inhibitor
CAS No. 732983-37-8
Formula C20H18N6O3
M. Wt 390.4
Purity >98%
Synonyms BAY61-3606, BAY-61-3606
SMILES COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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