Bcl-2 Family

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  1. Bcl-2 modulator

    BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
  2. F1F0-ATPase modulator

    Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.

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