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Begacestat (GSI-953)

Catalog No.: A11258

γ-secretase inhibitor

Begacestat (GSI-953)

Begacestat (GSI-953) Chemical Structure

CAS NO. 769169-27-9

Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Availability: In stock

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5 mg

Regular Price: $120.00

Special Price $96.00

10 mg

Regular Price: $200.00

Special Price $160.00

50 mg

Regular Price: $840.00

Special Price $672.00

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Biological Activity

Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.53 mL 127.64 mL 255.27 mL
0.5 mM 5.11 mL 25.53 mL 51.05 mL
1 mM 2.55 mL 12.76 mL 25.53 mL
5 mM 0.51 mL 2.55 mL 5.11 mL

*The above data is based on the productmolecular weight 391.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11258
Actions Inhibitor
CAS No. 769169-27-9
Formula C9H8ClF6NO3S2
M. Wt 391.74
Purity >98%
Synonyms GSI953, GSI 953
SMILES C1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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