Begacestat (GSI-953)

Catalog No.: A11258

γ-secretase inhibitor

Begacestat (GSI-953)

Begacestat (GSI-953) Chemical Structure

CAS NO. 769169-27-9

Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
50 mg
$840.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.53 mL 127.64 mL 255.27 mL
0.5 mM 5.11 mL 25.53 mL 51.05 mL
1 mM 2.55 mL 12.76 mL 25.53 mL
5 mM 0.51 mL 2.55 mL 5.11 mL

*The above data is based on the productmolecular weight 391.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11258
Actions Inhibitor
M. Wt 391.74
Formula C9H8ClF6NO3S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 769169-27-9
Synonyms GSI953, GSI 953
SMILES C1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F

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