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β-Amyloid
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | Beta Amyloid | Other |
|---|---|---|---|
| A10288 | DAPT (GSI-IX) | ** | |
| A10802 | RO4929097 | *** | γ secretase,γ secretase(ICN) |
| A11194 | MK-0752 | *** | |
| A10157 | Avagacestat | **** | |
| A11776 | LY2811376 | * | BACE1 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
18 Item(s)
per page
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A10802 SALE |
RO4929097 |
Gamma-secretase inhibitor |
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
|
A10157 |
BMS-708163 (Avagacestat) |
Gamma-secretase inhibitor |
BMS-708163 is an oral gamma secretase inhibitor designed for selective
inhibition of amyloid beta synthesis.
|
A11194 SALE |
MK-0752 |
Gamma-secretase inhibitor |
MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
|
A10312 SALE |
Dimebon 2HCl |
Neuroprotectant |
Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities.
|
A11776 SALE |
LY2811376 |
BACE1 inhibitor |
LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
|
A12647 |
Ro 90-7501 |
amyloid β42 inhibitor |
Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).
|
A15424 |
Amyloid b-Protein (1-15)
|
- |
Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
|
A15423 |
beta-Amyloid (1-11)
|
- |
Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
|
A15421 |
Amyloid b-Peptide (1-43) (human)
|
- |
Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
|
A15420 |
Amyloid b-peptide (1-42) (rat)
|
- |
Amyloid b-peptide (1-42) (rat)
|
A15419 |
Amyloid b-peptide (1-40) (rat)
|
- |
Amyloid b-peptide (1-40) (rat)
|
A15418 |
Amyloid b-Peptide (1-40) (human)
|
- |
Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).
|
A15416 SALE |
Amyloid b-peptide (25-35) (human) |
- |
Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.
|
A15417 |
Amyloid b-Peptide (12-28) (human)
|
- |
Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.
|
A15415 |
Amyloid b-Peptide (10-20) (human)
|
- |
Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
|
A15414 |
Amyloid b-peptide (42-1) (human)
|
- |
Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
|
A14075 |
Amyloid b-Peptide (1-42) (human) |
- |
Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
|
A13094 |
alpha-Amyloid Precursor Protein Modulator |
- |
|
18 Item(s)
per page
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