β-Amyloid

Catalog No.Inhibitor Name Beta AmyloidOther
A10288DAPT (GSI-IX)
**
A10802RO4929097
***
γ secretase,γ secretase(ICN)
A11194MK-0752
***
A10157Avagacestat
****
A11776LY2811376
*
BACE1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

22 Item(s)

per page

Set Descending Direction
  1. gamma-Secretase Modulators

    Catalog No. A11426
    Quick View
    Amyloid-β production inhibitor
    gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease. Learn More
  2. ALZ-801

    Catalog No. A18744
    Quick View
    β-amyloid (Aβ) inhibitor
    ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation for Alzheimer's disease (AD). ALZ-801 is a prodrug of tramiprosate with improved pharmacokinetic properties and gastrointestinal tolerability. Learn More
  3. Aftin-4

    Catalog No. A17139
    Quick View
    Amyloid-β42 Inducer
    Aftin-4 is an amyloid-β42 inducer that electively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Learn More
  4. RO4929097

    Catalog No. A10802
    Quick View
    Gamma-secretase inhibitor
    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More
  5. ARN2966

    Catalog No. A21016
    Quick View
    APP expression modulator
    ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. Learn More
  6. BMS-708163 (Avagacestat)

    Catalog No. A10157
    Quick View
    Gamma-secretase inhibitor
    BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis. Learn More
  7. MK-0752

    Catalog No. A11194
    Quick View
    Gamma-secretase inhibitor
    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. Learn More
  8. LY2811376

    Catalog No. A11776
    Quick View
    BACE1 inhibitor
    LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More
  9. Dimebon 2HCl

    Catalog No. A10312
    Quick View
    Neuroprotectant
    Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities. Learn More
  10. Ro 90-7501

    Catalog No. A12647
    Quick View
    amyloid β42 inhibitor
    Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM). Learn More
  11. Amyloid b-Protein (1-15)

    Catalog No. A15424
    Quick View
    Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Learn More
  12. beta-Amyloid (1-11)

    Catalog No. A15423
    Quick View
    Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. Learn More
  13. Amyloid b-Peptide (1-43) (human)

    Catalog No. A15421
    Quick View
    Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42. Learn More
  14. Amyloid b-peptide (1-42) (rat)

    Catalog No. A15420
    Quick View
    Amyloid b-peptide (1-42) (rat) Learn More
  15. Amyloid b-peptide (1-40) (rat)

    Catalog No. A15419
    Quick View
    Amyloid b-peptide (1-40) (rat) Learn More
  16. Amyloid b-Peptide (1-40) (human)

    Catalog No. A15418
    Quick View
    Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP). Learn More
  17. Amyloid b-peptide (25-35) (human)

    Catalog No. A15416
    Quick View
    Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Learn More
  18. Amyloid b-Peptide (12-28) (human)

    Catalog No. A15417
    Quick View
    Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins. Learn More
  19. Amyloid b-Peptide (10-20) (human)

    Catalog No. A15415
    Quick View
    Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17. Learn More
  20. Amyloid b-peptide (42-1) (human)

    Catalog No. A15414
    Quick View
    Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide. Learn More
  21. Amyloid b-Peptide (1-42) (human)

    Catalog No. A14075
    Quick View
    Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Learn More
  22. alpha-Amyloid Precursor Protein Modulator

    Catalog No. A13094
    Quick View
    alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas. Learn More

22 Item(s)

per page

Set Descending Direction
Rewards