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$0.00 β-Amyloid
| Catalog No. | Inhibitor Name | Beta Amyloid | Other |
|---|---|---|---|
| A10288 | DAPT (GSI-IX) | ** | |
| A10802 | RO4929097 | *** | γ secretase,γ secretase(ICN) |
| A11194 | MK-0752 | *** | |
| A10157 | Avagacestat | **** | |
| A11776 | LY2811376 | * | BACE1 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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gamma-Secretase Modulators
Catalog No. A11426 Amyloid-β production inhibitorgamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease. Learn More -
Aftin-4
Catalog No. A17139 Amyloid-β42 InducerAftin-4 is an amyloid-β42 inducer that electively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Learn More -
RO4929097
Catalog No. A10802 Gamma-secretase inhibitorRO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More -
ARN2966
Catalog No. A21016 APP expression modulatorARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. Learn More -
BMS-708163 (Avagacestat)
Catalog No. A10157 Gamma-secretase inhibitorBMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis. Learn More -
LY2811376
Catalog No. A11776 BACE1 inhibitorLY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More -
MK-0752
Catalog No. A11194 Gamma-secretase inhibitorMK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. Learn More -
Dimebon 2HCl
Catalog No. A10312 NeuroprotectantDimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities. Learn More -
Ro 90-7501
Catalog No. A12647 amyloid β42 inhibitorRo 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM). Learn More -
Amyloid b-Protein (1-15)
Catalog No. A15424 Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Learn More -
beta-Amyloid (1-11)
Catalog No. A15423 Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. Learn More -
Amyloid b-Peptide (1-43) (human)
Catalog No. A15421 Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42. Learn More -
Amyloid b-Peptide (1-40) (human)
Catalog No. A15418 Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP). Learn More -
Amyloid b-peptide (25-35) (human)
Catalog No. A15416 Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Learn More -
Amyloid b-Peptide (12-28) (human)
Catalog No. A15417 Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins. Learn More -
Amyloid b-Peptide (10-20) (human)
Catalog No. A15415 Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17. Learn More -
Amyloid b-peptide (42-1) (human)
Catalog No. A15414 Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide. Learn More -
Amyloid b-Peptide (1-42) (human)
Catalog No. A14075 Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Learn More -
alpha-Amyloid Precursor Protein Modulator
Catalog No. A13094 alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas. Learn More
21 Item(s)
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