β-Amyloid

Catalog No.Inhibitor Name Beta AmyloidOther
A10288DAPT (GSI-IX)
**
A10802RO4929097
***
γ secretase,γ secretase(ICN)
A11194MK-0752
***
A10157Avagacestat
****
A11776LY2811376
*
BACE1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. RO4929097

    Catalog No. A10802
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    Gamma-secretase inhibitor
    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More
  2. BMS-708163 (Avagacestat)

    Catalog No. A10157
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    Gamma-secretase inhibitor
    BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis. Learn More
  3. MK-0752

    Catalog No. A11194
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    Gamma-secretase inhibitor
    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. Learn More
  4. LY2811376

    Catalog No. A11776
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    BACE1 inhibitor
    LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More
  5. Dimebon 2HCl

    Catalog No. A10312
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    Neuroprotectant
    Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities. Learn More
  6. Ro 90-7501

    Catalog No. A12647
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    amyloid β42 inhibitor
    Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM). Learn More
  7. Amyloid b-Protein (1-15)

    Catalog No. A15424
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    Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Learn More
  8. beta-Amyloid (1-11)

    Catalog No. A15423
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    Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. Learn More
  9. Amyloid b-Peptide (1-43) (human)

    Catalog No. A15421
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    Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42. Learn More
  10. Amyloid b-peptide (1-42) (rat)

    Catalog No. A15420
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    Amyloid b-peptide (1-42) (rat) Learn More
  11. Amyloid b-peptide (1-40) (rat)

    Catalog No. A15419
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    Amyloid b-peptide (1-40) (rat) Learn More
  12. Amyloid b-Peptide (1-40) (human)

    Catalog No. A15418
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    Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP). Learn More
  13. Amyloid b-peptide (25-35) (human)

    Catalog No. A15416
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    Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Learn More
  14. Amyloid b-Peptide (12-28) (human)

    Catalog No. A15417
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    Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins. Learn More
  15. Amyloid b-Peptide (10-20) (human)

    Catalog No. A15415
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    Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17. Learn More
  16. Amyloid b-peptide (42-1) (human)

    Catalog No. A15414
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    Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide. Learn More
  17. Amyloid b-Peptide (1-42) (human)

    Catalog No. A14075
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    Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Learn More
  18. alpha-Amyloid Precursor Protein Modulator

    Catalog No. A13094
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    alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas. Learn More

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