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Biological Activity
BMS303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.
| In vitro | DMSO | 73 mg/mL (172.04 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.57 mL | 117.84 mL | 235.68 mL |
| 0.5 mM | 4.71 mL | 23.57 mL | 47.14 mL |
| 1 mM | 2.36 mL | 11.78 mL | 23.57 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
*The above data is based on the productmolecular weight 424.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13807 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 943962-47-8 |
| Formula | C19H15Cl2NO4S |
| M. Wt | 424.3 |
| Purity | >98% |
| Synonyms | BMS 303141, BMS-303141 |
| SMILES | COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC(=CC(=C3O)Cl)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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