BMY 7378

Catalog No.: A11208

5-HT1A agonist

BMY 7378 Chemical Structure

CAS NO. 21102-95-4

BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $40.00

Special Price $32.00

50 mg

Regular Price: $85.00

Special Price $68.00

200 mg

Regular Price: $320.00

Special Price $256.00

10mM * 1mL in DMSO
$77.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.
Targets
Target Value
5-HT1ApIC50: 8.3
α1D-adrenoceptorpki: 8.2
DopamineD2receptorpIC50: 7.4
α2C-adrenoceptorpki: 6.54
5-HT1CpIC50: 6.4
5-HT1DpIC50: 5.9
H1receptorpIC50: 5.7
5-HT2pIC50: 5.5
H2receptorpIC50: 5.3
α2-adrenoceptor pIC50: 5.1
β1-adrenoceptor pIC50: 5.1
DopamineD1receptorpIC50: 5
NicotinicreceptorpIC50: 4.9
β2-adrenoceptor pIC50: <5.0
5-HT3pIC50: <5.0
H3receptorpIC50: <5.0
GABAAreceptorpIC50: <5.0
GABABreceptorpIC50: <5.0
MuscarinicM1receptorpIC50: <5.0
MuscarinicM2receptorpIC50: <5.0
MuscarinicM3receptorpIC50: <5.0
NMDAreceptorpIC50: <5.0
AT1receptorpIC50: <5.0
AT2receptorpIC50: <5.0
EndothelinReceptorpIC50: <5.0
AdenosineA1receptorpIC50: <5.0
AdenosineA2receptorpIC50: <5.0
In vitro (25°C) DMSO 92 mg/mL (200.68 mM)
Water 92 mg/mL (200.68 mM)
Ethanol 20 mg/mL (43.62 mM)
In vivo Saline 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.81 mL 109.07 mL 218.14 mL
0.5 mM 4.36 mL 21.81 mL 43.63 mL
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL

*The above data is based on the productmolecular weight 458.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11208
Actions Agonist
M. Wt 458.42
Formula C22H31N3O3.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 21102-95-4
Synonyms BMY7378, BMY-7378
SMILES COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl

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