BMY 7378

Catalog No.: A11208

5-HT1A agonist

BMY 7378

BMY 7378 Chemical Structure

CAS NO. 21102-95-4

BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.

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10 mg

Regular Price: $40.00

Special Price $32.00

50 mg

Regular Price: $85.00

Special Price $68.00

200 mg

Regular Price: $320.00

Special Price $256.00

10mM * 1mL in DMSO

Regular Price: $77.00

Special Price $61.60

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Biological Activity

BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.
Targets
Target Value
5-HT1ApIC50: 8.3
α1D-adrenoceptorpki: 8.2
DopamineD2receptorpIC50: 7.4
α2C-adrenoceptorpki: 6.54
5-HT1CpIC50: 6.4
5-HT1DpIC50: 5.9
H1receptorpIC50: 5.7
5-HT2pIC50: 5.5
H2receptorpIC50: 5.3
α2-adrenoceptor pIC50: 5.1
β1-adrenoceptor pIC50: 5.1
DopamineD1receptorpIC50: 5
NicotinicreceptorpIC50: 4.9
β2-adrenoceptor pIC50: <5.0
5-HT3pIC50: <5.0
H3receptorpIC50: <5.0
GABAAreceptorpIC50: <5.0
GABABreceptorpIC50: <5.0
MuscarinicM1receptorpIC50: <5.0
MuscarinicM2receptorpIC50: <5.0
MuscarinicM3receptorpIC50: <5.0
NMDAreceptorpIC50: <5.0
AT1receptorpIC50: <5.0
AT2receptorpIC50: <5.0
EndothelinReceptorpIC50: <5.0
AdenosineA1receptorpIC50: <5.0
AdenosineA2receptorpIC50: <5.0
In vitro (25°C) DMSO 81 mg/mL (176.69 mM)
Water 81 mg/mL (176.69 mM)
Ethanol 18 mg/mL (39.26 mM)
In vivo Saline 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.81 mL 109.07 mL 218.14 mL
0.5 mM 4.36 mL 21.81 mL 43.63 mL
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL

*The above data is based on the productmolecular weight 458.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11208
Actions Agonist
CAS No. 21102-95-4
Formula C22H31N3O3.2HCl
M. Wt 458.42
Solubility DMSO
Purity >98%
Synonyms BMY7378, BMY-7378
SMILES COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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