Bosentan

Catalog No.: A11091

ETAR/ETBR inhibitor

Bosentan

Bosentan Chemical Structure

CAS NO. 147536-97-8

Bosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.

Availability: In stock

Package Price Qty
25 mg
$40.00
50 mg
$70.00
100 mg
$120.00
200 mg
$200.00
10mM * 1mL in DMSO
$68.00
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Biological Activity

Bosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
Targets
ET-A ET-B
4.7 nM(Ki)95 nM(Ki)
In vitro DMSO 100 mg/mL (181.28 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.43 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.13 mL 90.65 mL 181.29 mL
0.5 mM 3.63 mL 18.13 mL 36.26 mL
1 mM 1.81 mL 9.06 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL

*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11091
Actions Inhibitor
M. Wt 551.6
Formula C27H29N5O6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 147536-97-8
SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC

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