Bosentan

Catalog No.: A11091

ETAR/ETBR inhibitor

Bosentan

Bosentan Chemical Structure

CAS NO. 147536-97-8

Bosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.

Availability: In stock

Package Price Qty
25 mg
$40.00
50 mg
$70.00
100 mg
$120.00
200 mg
$200.00
10mM * 1mL in DMSO
$68.00
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Biological Activity

Bosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
Targets
ET-A ET-B
4.7 nM(Ki)95 nM(Ki)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.13 mL 90.65 mL 181.29 mL
0.5 mM 3.63 mL 18.13 mL 36.26 mL
1 mM 1.81 mL 9.06 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL

*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11091
Actions Inhibitor
CAS No. 147536-97-8
Formula C27H29N5O6S
M. Wt 551.6
Solubility DMSO
Purity >98%
SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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