Brivanib alaninate (BMS-582664)

Name: Brivanib alaninate (BMS-582664)
Brand: Adooq Bioscience
SKU: A10162
Rating: 100 (268 reviews)

Catalog No.: A10162

VEGFR inhibitor

Brivanib alaninate (BMS-582664) Chemical Structure

CAS NO. 649735-63-7

Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$168.00
25 mg	$368.00
50 mg	$688.00
10mM * 1mL in DMSO	$138.00
Custom Size	Get quote

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Biological Activity

Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling.

Targets

VEGFR2	Flk1	FGFR1	VEGFR1
25 nM	89 nM	148 nM	380 nM

Solubility *

In vitro (25°C)	DMSO	83 mg/mL (188 mM)
	Water	Insoluble
	Ethanol	83 mg/mL (188 mM)
In vivo	0.5% methylcellulose+0.2% Tween 80	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.65 mL	113.25 mL	226.5 mL
0.5 mM	4.53 mL	22.65 mL	45.3 mL
1 mM	2.27 mL	11.33 mL	22.65 mL
5 mM	0.45 mL	2.27 mL	4.53 mL

*The above data is based on the productmolecular weight 441.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10162
Actions	Inhibitor
CAS No.	649735-63-7
Formula	C22H24FN5O4
M. Wt	441.5
Purity	>98%
Synonyms	BMS582664
SMILES	CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[[email protected]@H](C)OC(=O)[[email protected]](C)N)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.